Hypoalgesic placebo effects can occur with transparent disclosures Colloca, Luana Colloca, Luana Less PAIN. 158(12):2279-2280, December 2017. Favorite PDF Permissions Buy
Shedding light on the contribution of different c-fibre nociceptors to nocifensive behavior Lechner, Stefan G. Lechner, Stefan G. Less PAIN. 158(12):2281-2282, December 2017. Favorite PDF Permissions Buy
Hijacking the endogenous opioid system to treat pain: who thought it would be so complicated? Clauw, Daniel Clauw, Daniel Less PAIN. 158(12):2283-2284, December 2017. Favorite PDF Permissions Buy
Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia La, Jun-Ho; Chung, Jin Mo La, Jun-Ho; Chung, Jin Mo Less PAIN. 158(12):2285-2289, December 2017. Favorite PDF Permissions Buy
Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment Ballantyne, Jane C.; Sullivan, Mark D. Ballantyne, Jane C.; Sullivan, Mark D. Less PAIN. 158(12):2290-2300, December 2017. Abstract Abstract Favorite PDF Permissions Buy SDC
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide Moutal, Aubin; Yang, Xiaofang; Li, Wennan; More Moutal, Aubin; Yang, Xiaofang; Li, Wennan; Gilbraith, Kerry B.; Luo, Shizhen; Cai, Song; François-Moutal, Liberty; Chew, Lindsey A.; Yeon, Seul Ki; Bellampalli, Shreya S.; Qu, Chaoling; Xie, Jennifer Y.; Ibrahim, Mohab M.; Khanna, May; Park, Ki Duk; Porreca, Frank; Khanna, Rajesh Less PAIN. 158(12):2301-2319, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Prevention of CRMP2 phosphorylation by (S)-lacosamide reverses neurofibromatosis type 1 (NF1)-related neuronal excitability and pain induced by Nf1 gene editing. Buy SDC
Is the rationale more important than deception? A randomized controlled trial of open-label placebo analgesia Locher, Cosima; Frey Nascimento, Antje; Kirsch, Irving; More Locher, Cosima; Frey Nascimento, Antje; Kirsch, Irving; Kossowsky, Joe; Meyer, Andrea; Gaab, Jens Less PAIN. 158(12):2320-2328, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: In a standardised heat pain paradigm randomized controlled trial with healthy participants, open-label placebos did not significantly differ from deceptive placebos, regarding subjective intensity and unpleasantness ratings. Buy SDC
Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers Beaudry, Hélène; Daou, Ihab; Ase, Ariel R.; More Beaudry, Hélène; Daou, Ihab; Ase, Ariel R.; Ribeiro-da-Silva, Alfredo; Séguéla, Philippe Less PAIN. 158(12):2329-2339, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The functional control of 2 classes of peripheral unmyelinated nociceptors with distinct functions, TRPV1+ and MrgD+ C-fibers, is achieved optogenetically with high spatiotemporal precision. Buy SDC
Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study Raputova, Jana; Srotova, Iva; Vlckova, Eva; More Raputova, Jana; Srotova, Iva; Vlckova, Eva; Sommer, Claudia; ĂœĂ§eyler, Nurcan; Birklein, Frank; Rittner, Heike L.; Rebhorn, Cora; Adamova, Blanka; Kovalova, Ivana; Kralickova Nekvapilova, Eva; Forer, Lucas; Belobradkova, Jana; Olsovsky, Jindrich; Weber, Pavel; Dusek, Ladislav; Jarkovsky, Jiri; Bednarik, Josef Less PAIN. 158(12):2340-2353, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Cross-sectional observational study in a cohort of 232 diabetic polyneuropathy patients confirmed higher severity of neuropathy and predominant loss-of-function sensory profile in painful cases. Go to Full Text of this Article Open SDC
Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster-randomized controlled trial Lumley, Mark A.; Schubiner, Howard; Lockhart, Nancy A.; More Lumley, Mark A.; Schubiner, Howard; Lockhart, Nancy A.; Kidwell, Kelley M.; Harte, Steven E.; Clauw, Daniel J.; Williams, David A. Less PAIN. 158(12):2354-2363, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Emotional awareness and expression therapy targets stress and psychosocial adversity. In fibromyalgia, emotional awareness and expression therapy was more effective than fibromyalgia education and surpassed cognitive behavioral therapy on pain reduction. Buy
Cerebral white matter structure is disrupted in Gulf War Veterans with chronic musculoskeletal pain Van Riper, Stephanie M.; Alexander, Andrew L.; Koltyn, Kelli F.; More Van Riper, Stephanie M.; Alexander, Andrew L.; Koltyn, Kelli F.; Stegner, Aaron J.; Ellingson, Laura D.; Destiche, Daniel J.; Dougherty, Ryan J.; Lindheimer, Jacob B.; Cook, Dane B. Less PAIN. 158(12):2364-2375, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Widespread disruption of cerebral white matter microstructure across brain regions implicated in pain regulation was observed in Gulf War Veterans suffering from chronic pain. Buy SDC
Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model Kim, Hyunyoung; Thompson, Jeremy; Ji, Guangchen; More Kim, Hyunyoung; Thompson, Jeremy; Ji, Guangchen; Ganapathy, Vadivel; Neugebauer, Volker Less PAIN. 158(12):2376-2385, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Monomethyl fumarate (MMF), which has neuroprotective and antioxidant properties, inhibited behavioral responses and neuronal activity in the amygdala in a rat model of arthritis pain. Buy
Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain Bannister, Kirsty; Qu, Chaoling; Navratilova, Edita; More Bannister, Kirsty; Qu, Chaoling; Navratilova, Edita; Oyarzo, Janice; Xie, Jennifer Yanhua; King, Tamara; Dickenson, Anthony H.; Porreca, Frank Less PAIN. 158(12):2386-2395, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Gabapentin engages endogenous opioid signaling in the anterior cingulate cortex to selectively relieve affective qualities of peripheral nerve injury–induced ongoing pain and in the spinal cord to inhibit nociceptive neuronal excitability and evoked hypersensitivity. Buy
Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation Scheff, Nicole N.; Ye, Yi; Bhattacharya, Aditi; More Scheff, Nicole N.; Ye, Yi; Bhattacharya, Aditi; MacRae, Justin; Hickman, Dustin N.; Sharma, Atul K.; Dolan, John C.; Schmidt, Brian L. Less PAIN. 158(12):2396-2409, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Two oral cancer pain models were used to demonstrate that cancer-secreted tumor necrosis factor alpha drives nociceptive behavior and T-cell infiltration into the microenvironment. Buy
Passive transfer autoimmunity in a mouse model of complex regional pain syndrome Guo, Tian-Zhi; Shi, Xiaoyou; Li, Wen-Wu; More Guo, Tian-Zhi; Shi, Xiaoyou; Li, Wen-Wu; Wei, Tzuping; Clark, John David; Kingery, Wade S. Less PAIN. 158(12):2410-2421, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: IgM-mediated autoimmunity supports nocicieptive sensitization in a mouse fracture model of complex regional pain syndrome. Buy
Opioid prescription levels and postoperative outcomes in orthopedic surgery Cozowicz, Crispiana; Olson, Ashley; Poeran, Jashvant; More Cozowicz, Crispiana; Olson, Ashley; Poeran, Jashvant; Mörwald, Eva E.; Zubizarreta, Nicole; Girardi, Federico P.; Hughes, Alexander P.; Mazumdar, Madhu; Memtsoudis, Stavros G. Less PAIN. 158(12):2422-2430, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: A stepwise opioid dose–dependent increase in numerous postoperative complications, cost, and length of stay was observed suggesting a dose–response gradient. Buy SDC
Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice Peterson, Cristina D.; Kitto, Kelley F.; AkgĂ¼n, Eyup; More Peterson, Cristina D.; Kitto, Kelley F.; AkgĂ¼n, Eyup; Lunzer, Mary M.; Riedl, Maureen S.; Vulchanova, Lucy; Wilcox, George L.; Portoghese, Philip S.; Fairbanks, Carolyn A. Less PAIN. 158(12):2431-2441, December 2017. Abstract Abstract Favorite PDF Permissions Buy
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis Philpott, Holly T.; O'Brien, Melissa; McDougall, Jason J. Philpott, Holly T.; O'Brien, Melissa; McDougall, Jason J. Less PAIN. 158(12):2442-2451, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: The nonpsychoactive cannabis-derivative cannabidiol (CBD) reduced nociceptor activity and pain in end-stage osteoarthritis. Prophylactic treatment with CBD prevented joint neuropathy and chronic neuropathic pain. Go to Full Text of this Article Open
Cannabis constituent synergy in a mouse neuropathic pain model Casey, Sherelle L.; Atwal, Nicholas; Vaughan, Christopher W. Casey, Sherelle L.; Atwal, Nicholas; Vaughan, Christopher W. Less PAIN. 158(12):2452-2460, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Combination treatment with the phytocannabinoids THC and cannabidiol synergistically reduces allodynia in a neuropathic pain model. The observed drug interaction proffers 2 divergent treatment regimes. Buy
MicroRNA–mediated downregulation of potassium-chloride-cotransporter and vesicular γ-aminobutyric acid transporter expression in spinal cord contributes to neonatal cystitis–induced visceral pain in rats Zhang, Jian; Yu, James; Kannampalli, Pradeep; More Zhang, Jian; Yu, James; Kannampalli, Pradeep; Nie, Linghui; Meng, Hui; Medda, Bidyut K.; Shaker, Reza; Sengupta, Jyoti N.; Banerjee, Banani Less PAIN. 158(12):2461-2474, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: This study emphasizes that the miRNA-mediated downregulation of spinal GABAergic function in zymosan-induced cystitis may play a role in the development of chronic pelvic pain. Buy
Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith–Lemli–Opitz syndrome Babes, Alexandru; Ciotu, Cosmin I.; Hoffmann, Tal; More Babes, Alexandru; Ciotu, Cosmin I.; Hoffmann, Tal; Kichko, Tatjana I.; Selescu, Tudor; Neacsu, Cristian; Sauer, Susanne K.; Reeh, Peter W.; Fischer, Michael J.M. Less PAIN. 158(12):2475-2486, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: 7-dehydrocholesterol, a cholesterol precursor, facilitates free radical generation through ultraviolet light. Two TRP ion channels are the principal receptors transducing this into nociceptor activation. Buy SDC
High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls Bäckryd, Emmanuel; Lind, Anne-Li; Thulin, MĂ¥ns; More Bäckryd, Emmanuel; Lind, Anne-Li; Thulin, MĂ¥ns; Larsson, Anders; Gerdle, Björn; Gordh, Torsten Less PAIN. 158(12):2487-2495, December 2017. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: According to animal models, neuroinflammation is a major feature of neuropathic pain. The present findings confirm that this hypothesis is of relevance to humans. Go to Full Text of this Article Open
Cardiac vagal tone as a reliable index of pain chronicity and severity Davydov, Dmitry M. Davydov, Dmitry M. Less PAIN. 158(12):2496-2497, December 2017. Favorite PDF Permissions Buy
Reply Bruehl, Stephen; Walker, Lynn S.; Smith, Craig A.; More Bruehl, Stephen; Walker, Lynn S.; Smith, Craig A.; on behalf of co-authors Less PAIN. 158(12):2497-2498, December 2017. Favorite PDF Permissions Buy
Reporting randomized controlled trial quality and search date in systematic reviews and meta-analyses Puljak, Livia Puljak, Livia Less PAIN. 158(12):2498-2499, December 2017. Favorite PDF Permissions Buy
Reply MacPherson, Hugh; Vertosick, Emily Ann; Vickers, Andrew Julian MacPherson, Hugh; Vertosick, Emily Ann; Vickers, Andrew Julian Less PAIN. 158(12):2499-2500, December 2017. Favorite PDF Permissions Buy
