Getting personal: the role of individual patient preferences and characteristics in shaping pain treatment outcomes Lazaridou, Asimina; Edwards, Robert R. Lazaridou, Asimina; Edwards, Robert R. Less PAIN. 157(1):1-2, January 2016. Favorite PDF Permissions Buy
The fifth vital sign revisited Campbell, James N. Campbell, James N. Less PAIN. 157(1):3-4, January 2016. Favorite PDF Permissions Free
Altered brain connectivity in dysmenorrhea: pain modulation and the motor cortex Kutch, Jason J.; Tu, Frank F. Kutch, Jason J.; Tu, Frank F. Less PAIN. 157(1):5-6, January 2016. Favorite PDF Permissions Buy
Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation Tracy, Lincoln M.; Ioannou, Liane; Baker, Katharine S.; More Tracy, Lincoln M.; Ioannou, Liane; Baker, Katharine S.; Gibson, Stephen J.; Georgiou-Karistianis, Nellie; Giummarra, Melita J. Less PAIN. 157(1):7-29, January 2016. Abstract Abstract Favorite PDF Permissions Buy SDC
A systematic review and meta-analysis of risk factors for postherpetic neuralgia Forbes, Harriet J.; Thomas, Sara L.; Smeeth, Liam; More Forbes, Harriet J.; Thomas, Sara L.; Smeeth, Liam; Clayton, Tim; Farmer, Ruth; Bhaskaran, Krishnan; Langan, Sinéad M. Less PAIN. 157(1):30-54, January 2016. Abstract Abstract Favorite PDF Permissions Go to Full Text of this Article Open SDC
A systematic review and meta-analysis of the prevalence of chronic widespread pain in the general population Mansfield, Kathryn E.; Sim, Julius; Jordan, Joanne L.; More Mansfield, Kathryn E.; Sim, Julius; Jordan, Joanne L.; Jordan, Kelvin P. Less PAIN. 157(1):55-64, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: One in 10 adults report chronic widespread pain with potential sociocultural variation. Cultural differences in pain reporting should be considered in future research. Go to Full Text of this Article Open SDC
Must we reduce pain intensity to treat chronic pain? Sullivan, Mark D.; Ballantyne, Jane C. Sullivan, Mark D.; Ballantyne, Jane C. Less PAIN. 157(1):65-69, January 2016. Favorite PDF Permissions Buy
Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice Leung, Audrey; Gregory, Nicholas S.; Allen, Lee-Ann H.; More Leung, Audrey; Gregory, Nicholas S.; Allen, Lee-Ann H.; Sluka, Kathleen A. Less PAIN. 157(1):70-79, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Regular physical activity increases the percentage of M2 macrophages and prevents the development of chronic muscle hyperalgesia through activation of muscle interleukin-10 receptors. Buy
Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells Iuvone, Teresa; Affaitati, Giannapia; De Filippis, Daniele; More Iuvone, Teresa; Affaitati, Giannapia; De Filippis, Daniele; Lopopolo, Mariangela; Grassia, Gianluca; Lapenna, Domenico; Negro, Luana; Costantini, Raffaele; Vaia, Massimo; Cipollone, Francesco; Ialenti, Armando; Giamberardino, Maria Adele Less PAIN. 157(1):80-91, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: In rats with endometriosis plus ureteral calculosis, oral ultramicronized palmitoylethanolamide vs placebo significantly reduces viscerovisceral hyperalgesia by downregulating mast cell activity in endometriotic lesions. Buy
Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea Wei, Shyh-Yuh; Chao, Hsiang-Tai; Tu, Cheng-Hao; More Wei, Shyh-Yuh; Chao, Hsiang-Tai; Tu, Cheng-Hao; Li, Wei-Chi; Low, Intan; Chuang, Chih-Ying; Chen, Li-Fen; Hsieh, Jen-Chuen Less PAIN. 157(1):92-102, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Maladaptive neuroplasticity of the descending pain modulatory systems in dysmenorrhic women that might be relevant to the development of co-occurring functional disorders later in life. Buy SDC
Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte–neuronal function in rats with L5 spinal nerve ligation model Liu, Xiaoming; Liu, Hongjun; Xu, Shuangshuang; More Liu, Xiaoming; Liu, Hongjun; Xu, Shuangshuang; Tang, Zongxiang; Xia, Weiliang; Cheng, Zhuqiang; Li, Weiyan; Jin, Yi Less PAIN. 157(1):103-116, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Early translocator protein upregulation inhibits spinal astrocytes activation and p-JNK1–CXCL1-CXCR2 signaling pathway and elicits potent analgesic effects against chronic neuropathic pain. Buy
Pain and motor processing in the human cerebellum Coombes, Stephen A.; Misra, Gaurav Coombes, Stephen A.; Misra, Gaurav Less PAIN. 157(1):117-127, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Common activation for pain and motor processing extends beyond cerebellar motor maps to the posterior cerebellum, implicating the posterior cerebellum in pain-related motor adaptation. Buy
Translation of random painful stimuli into numerical responses in fibromyalgia and perioperative patients Oudejans, Linda; van Velzen, Monique; Olofsen, Erik; More Oudejans, Linda; van Velzen, Monique; Olofsen, Erik; Beun, Robert; Dahan, Albert; Niesters, Marieke Less PAIN. 157(1):128-136, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Consistency to grade experimental pain using numerical rating is high in healthy controls but deteriorates in chronic but not acute pain and during opioid administration. Buy
Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation Pritchard, Rory A.; Falk, Lovissa; Larsson, Mathilda; More Pritchard, Rory A.; Falk, Lovissa; Larsson, Mathilda; Leinders, Mathias; Sorkin, Linda S. Less PAIN. 157(1):137-146, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: PI3K-α, -δ, and -γ all participate in inflammation induction. Antagonism of only PI3K-γ blocks nociception, which is indicative of a role for this isoform within the afferent. Go to Full Text of this Article Open
GluN2B N-methyl-D-aspartate receptor and excitatory amino acid transporter 3 are upregulated in primary sensory neurons after 7 days of morphine administration in rats: implication for opiate-induced hyperalgesia Gong, Kerui; Bhargava, Aditi; Jasmin, Luc Gong, Kerui; Bhargava, Aditi; Jasmin, Luc Less PAIN. 157(1):147-158, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Sustained morphine leads to greater excitability and upregulation of the GluN2B containing N-methyl-D-aspartate receptors as well as the glutamate transporter EAAT3/EAAC1 in peripheral nociceptive neurons. Buy
Frequency, impact, and predictors of persistent pain after root canal treatment: a national dental PBRN study Nixdorf, Donald R.; Law, Alan S.; Lindquist, Kimberly; More Nixdorf, Donald R.; Law, Alan S.; Lindquist, Kimberly; Reams, Gregory J.; Cole, Emery; Kanter, Keith; Nguyen, Ruby H.N.; Harris, D. Robert; National Dental PBRN Collaborative Group Less PAIN. 157(1):159-165, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Patient age and sex, as well as dentist training, did not predict persistent pain after root canal treatment, whereas preoperative pain duration and the patient's expectation did. Buy SDC
Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons Harasawa, Ichiro; Johansen, Joshua P.; Fields, Howard L.; More Harasawa, Ichiro; Johansen, Joshua P.; Fields, Howard L.; Porreca, Frank; Meng, Ian D. Less PAIN. 157(1):166-173, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Ablation of μ-opioid receptor–expressing neurons in the rostral ventromedial medulla reduced the number of pain-facilitating neurons, yet rostral ventromedial medulla analgesia remained functionally intact. Buy
Internet-delivered cognitive-behavioral treatment for adolescents with chronic pain and their parents: a randomized controlled multicenter trial Palermo, Tonya M.; Law, Emily F.; Fales, Jessica; More Palermo, Tonya M.; Law, Emily F.; Fales, Jessica; Bromberg, Maggie H.; Jessen-Fiddick, Tricia; Tai, Gabrielle Less PAIN. 157(1):174-185, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Internet-delivered cognitive-behavioral therapy produced benefits in adolescent and parent outcomes, and it may address barriers to access to evidence-based psychological treatment for pediatric chronic pain. Buy
Separate and combined associations of pain and emotional exhaustion with sickness absence Saastamoinen, Peppiina; Leino-Arjas, Päivi; Rahkonen, Ossi; More Saastamoinen, Peppiina; Leino-Arjas, Päivi; Rahkonen, Ossi; Lahelma, Eero Less PAIN. 157(1):186-193, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Pain and emotional exhaustion tend to co-occur. When co-occurring they seem to exacerbate each other's effects on subsequent medically certified sickness absence. Buy
Chronic sensory stroke with and without central pain is associated with bilaterally distributed sensory abnormalities as detected by quantitative sensory testing Krause, Thomas; Asseyer, Susanna; Geisler, Frederik; More Krause, Thomas; Asseyer, Susanna; Geisler, Frederik; Fiebach, Jochen B.; Oeltjenbruns, Jochen; Kopf, Andreas; Villringer, Kersten; Villringer, Arno; Jungehulsing, Gerhard J. Less PAIN. 157(1):194-202, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Chronic stroke patients with and without central pain show considerable abnormalities on the ipsilesional body side, whereas sensory differences between patient groups are subtle. Buy SDC
Long-term cost-effectiveness of initiating treatment for painful diabetic neuropathy with pregabalin, duloxetine, gabapentin, or desipramine Bellows, Brandon K.; Nelson, Richard E.; Oderda, Gary M.; More Bellows, Brandon K.; Nelson, Richard E.; Oderda, Gary M.; LaFleur, Joanne Less PAIN. 157(1):203-213, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The results of this Markov model showed starting with desipramine or duloxetine was the most cost-effective treatment for painful diabetic neuropathy depending on the willingness-to-pay. Buy SDC
A novel human surrogate model of noninjurious sharp mechanical pain Shabes, Polina; Schloss, Natalie; Magerl, Walter; More Shabes, Polina; Schloss, Natalie; Magerl, Walter; Schmahl, Christian; Treede, Rolf-Detlef; Baumgärtner, Ulf Less PAIN. 157(1):214-224, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The “blade” is a noninvasive surrogate model that imitates the acute phase of sharp incision-like pain. This model is useful to study mechanisms of mechanical pain and self-injurious behavior. Buy SDC
Trajectories of acute low back pain: a latent class growth analysis Downie, Aron S.; Hancock, Mark J.; Rzewuska, Magdalena; More Downie, Aron S.; Hancock, Mark J.; Rzewuska, Magdalena; Williams, Christopher M.; Lin, Chung-Wei Christine; Maher, Christopher G. Less PAIN. 157(1):225-234, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Distinct pain trajectory groups were identified for people with acute low back pain presenting to primary care. Group membership profile was determined using baseline characteristics. Buy SDC
Abnormal trigeminal sensory processing in obese mice Rossi, Heather L.; Broadhurst, Kimberly A.; Luu, Anthony S.K.; More Rossi, Heather L.; Broadhurst, Kimberly A.; Luu, Anthony S.K.; Lara, Orlando; Kothari, Sunny D.; Mohapatra, Durga P.; Recober, Ana Less PAIN. 157(1):235-246, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Obese mice display photophobic behavior after stimulation of the trigeminal nerve (V2) with capsaicin. Cultured trigeminal neurons from obese mice show increased calcium influx response. Buy SDC
The role of pain acceptance on function in individuals with disabilities: a longitudinal study Jensen, Mark P.; Smith, Amanda E.; Alschuler, Kevin N.; More Jensen, Mark P.; Smith, Amanda E.; Alschuler, Kevin N.; Gillanders, David T.; Amtmann, Dagmar; Molton, Ivan R. Less PAIN. 157(1):247-254, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: More pain acceptance is associated with less increase in pain intensity and improved function over 3.5 years in individuals with chronic pain. Buy SDC
T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain LeBlanc, Brian W.; Lii, Theresa R.; Huang, Jian Jia; More LeBlanc, Brian W.; Lii, Theresa R.; Huang, Jian Jia; Chao, Yu-Chieh; Bowary, Paul M.; Cross, Brent S.; Lee, Margaret S.; Vera-Portocarrero, Louis P.; Saab, Carl Y. Less PAIN. 157(1):255-263, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Pain disrupts thalamocortical rhythms in the brain, whereas Z944, a novel T-type calcium channel blocker, reverses these changes. Buy SDC
A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain Viscusi, Eugene R.; Webster, Lynn; Kuss, Michael; More Viscusi, Eugene R.; Webster, Lynn; Kuss, Michael; Daniels, Stephen; Bolognese, James A.; Zuckerman, Seth; Soergel, David G.; Subach, Ruth Ann; Cook, Emily; Skobieranda, Franck Less PAIN. 157(1):264-272, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: TRV130, a G-protein-biased μ-opioid receptor ligand with little β-arrestin recruitment, produced analgesia in moderate-to-severe acute pain, suggesting efficacy with similar tolerability vs conventional opioids. Buy SDC
CRHBP polymorphisms predict chronic pain development following motor vehicle collision Linnstaedt, Sarah D.; Bortsov, Andrey V.; Soward, April C.; More Linnstaedt, Sarah D.; Bortsov, Andrey V.; Soward, April C.; Swor, Robert; Peak, David A.; Jones, Jeffrey; Rathlev, Niels; Lee, David C.; Domeier, Robert; Hendry, Phyllis L.; McLean, Samuel A. Less PAIN. 157(1):273-279, January 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The results of this paper support the hypothesis that the hypothalamic–pituitary–adrenal axis is involved in chronic pain pathogenesis following motor vehicle collision trauma. Buy SDC
Validity of enriched enrollment, randomized withdrawal trials Ruan, Xiulu; Kaye, Alan D. Ruan, Xiulu; Kaye, Alan D. Less PAIN. 157(1):280, January 2016. Favorite PDF Permissions Buy
Pitfalls in trials of “multimodal analgesia” Dahl, Joergen B. Dahl, Joergen B. Less PAIN. 157(1):280-281, January 2016. Favorite PDF Permissions Buy
Response: design challenges in trials of multimodal analgesia Lunn, Troels Haxholdt Lunn, Troels Haxholdt Less PAIN. 157(1):281, January 2016. Favorite PDF Permissions Buy
