Overactivity in daily life: a crucial step in understanding how to tailor treatments Murphy, Susan L. Murphy, Susan L. Less PAIN. 156(10):1831-1832, October 2015. Favorite PDF Permissions Buy
From Galton to genome-wide association studies: evaluation of genetic and environmental factors predisposing to widespread pain Chukhlovin, Alexey B. Chukhlovin, Alexey B. Less PAIN. 156(10):1833-1834, October 2015. Favorite PDF Permissions Buy
A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models Hooijmans, Carlijn R.; Geessink, Florentine J.; Ritskes-Hoitinga, Merel; More Hooijmans, Carlijn R.; Geessink, Florentine J.; Ritskes-Hoitinga, Merel; Scheffer, Gert-Jan Less PAIN. 156(10):1835-1844, October 2015. Abstract Abstract Favorite PDF Permissions Buy SDC
An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker Livshits, Gregory; Macgregor, Alexander J.; Gieger, Christian; More Livshits, Gregory; Macgregor, Alexander J.; Gieger, Christian; Malkin, Ida; Moayyeri, Alireza; Grallert, Harald; Emeny, Rebecca T.; Spector, Tim; Kastenmüller, Gabi; Williams, Frances M.K. Less PAIN. 156(10):1845-1851, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: An “omics” investigation of chronic widespread pain in 2 population samples reveals a genetic variant in CYP3A5 as underlying steroid hormone abnormalities seen in CWP. Go to Full Text of this Article Open
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization Shi, Xiaoyou; Guo, Tian-Zhi; Wei, Tzuping; More Shi, Xiaoyou; Guo, Tian-Zhi; Wei, Tzuping; Li, Wen-Wu; Clark, David J.; Kingery, Wade S. Less PAIN. 156(10):1852-1863, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Spinal neuropeptide signaling and inflammatory mediator expression supports nociceptive sensitization in a fracture model of complex regional pain syndrome. Buy
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats Remeniuk, Bethany; Sukhtankar, Devki; Okun, Alec; More Remeniuk, Bethany; Sukhtankar, Devki; Okun, Alec; Navratilova, Edita; Xie, Jennifer Y.; King, Tamara; Porreca, Frank Less PAIN. 156(10):1864-1873, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Behavioral and neurochemical analysis of ongoing bone cancer pain demonstrating that the intrinsic reward of morphine can be dissociated from the reward of pain relief. Buy
Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis Rabey, Martin; Slater, Helen; O'Sullivan, Peter; More Rabey, Martin; Slater, Helen; O'Sullivan, Peter; Beales, Darren; Smith, Anne Less PAIN. 156(10):1874-1884, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Three subgroups, statistically derived from a cohort with chronic low back pain, differed on temperature and pressure pain sensitivity, and associated biopsychosocial factors. Buy
The disruptive effects of pain on n-back task performance in a large general population sample Attridge, Nina; Noonan, Donna; Eccleston, Christopher; More Attridge, Nina; Noonan, Donna; Eccleston, Christopher; Keogh, Edmund Less PAIN. 156(10):1885-1891, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: A large general population sample completed an n-back task online. Those who were in pain made more false alarms than those who were pain free. Buy
Enhanced binding capability of nuclear factor-κB with demethylated P2X3 receptor gene contributes to cancer pain in rats Zhou, You-Lang; Jiang, Guo-Qin; Wei, Jinrong; More Zhou, You-Lang; Jiang, Guo-Qin; Wei, Jinrong; Zhang, Hong-Hong; Chen, Wei; Zhu, Hongyan; Hu, Shufen; Jiang, Xinghong; Xu, Guang-Yin Less PAIN. 156(10):1892-1905, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Epigenetic regulations of P2X3 receptors play a crucial role in cancer pain. Targeting p65 binding to demethylated P2X3 receptor gene suppresses cancer pain. Buy SDC
Distinct temporal filtering mechanisms are engaged during dynamic increases and decreases of noxious stimulus intensity Mørch, Carsten Dahl; Frahm, Ken Steffen; Coghill, Robert C.; More Mørch, Carsten Dahl; Frahm, Ken Steffen; Coghill, Robert C.; Arendt-Nielsen, Lars; Andersen, Ole Kæseler Less PAIN. 156(10):1906-1912, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Offset analgesia could be activated with a feedback-controlled near-infrared laser system. Larger and delayed response to temperature decrease than to temperature increase was observed. Buy
Can patients identify what triggers their back pain? Secondary analysis of a case-crossover study do Carmo Silva Parreira, Patricia; Maher, Chris G.; Latimer, Jane; More do Carmo Silva Parreira, Patricia; Maher, Chris G.; Latimer, Jane; Steffens, Daniel; Blyth, Fiona; Li, Qiang; Ferreira, Manuela L. Less PAIN. 156(10):1913-1919, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: There is evidence that patients can accurately nominate the activity that triggered their sudden-onset acute low back pain. Buy
The Pain Course: a randomised controlled trial examining an internet-delivered pain management program when provided with different levels of clinician support Dear, Blake F.; Gandy, Milena; Karin, Eyal; More Dear, Blake F.; Gandy, Milena; Karin, Eyal; Staples, Lauren G.; Johnston, Luke; Fogliati, Vincent J.; Wootton, Bethany M.; Terides, Matthew D.; Kayrouz, Rony; Perry, Kathryn Nicholson; Sharpe, Louise; Nicholas, Michael K.; Titov, Nickolai Less PAIN. 156(10):1920-1935, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: This study extends previous research and examined the outcomes of an internet-delivered pain management program when delivered with different levels of clinical support. Go to Full Text of this Article Open
Touch inhibits subcortical and cortical nociceptive responses Mancini, Flavia; Beaumont, Anne-Lise; Hu, Li; More Mancini, Flavia; Beaumont, Anne-Lise; Hu, Li; Haggard, Patrick; Iannetti, Gian Domenico D. Less PAIN. 156(10):1936-1944, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Touch inhibits Aδ and C-fibre cortical potentials. Touch also suppresses the nociceptive blink reflex, a response generated before nociceptive input reaches the cortex. Go to Full Text of this Article Open
Is temporal summation of pain and spinal nociception altered during normal aging? Marouf, Rafik; Piché, Mathieu; Rainville, Pierre Marouf, Rafik; Piché, Mathieu; Rainville, Pierre Less PAIN. 156(10):1945-1953, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Aging is accompanied by reduced efficacy of inhibitory processes and preserved facilitation of pain and spinal nociceptive responses. Buy
Inflammation-induced pain sensitization in men and women: does sex matter in experimental endotoxemia? Wegner, Alexander; Elsenbruch, Sigrid; Rebernik, Laura; More Wegner, Alexander; Elsenbruch, Sigrid; Rebernik, Laura; Roderigo, Till; Engelbrecht, Elisa; Jäger, Marcus; Engler, Harald; Schedlowski, Manfred; Benson, Sven Less PAIN. 156(10):1954-1964, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Endotoxin-induced systemic immune activation leads to visceral and musculoskeletal hyperalgesia in healthy humans, irrespective of biological sex. Buy
Molecular genetic mechanisms of allelic specific regulation of murine Comt expression Segall, Samantha K.; Shabalina, Svetlana A.; Meloto, Carolina B.; More Segall, Samantha K.; Shabalina, Svetlana A.; Meloto, Carolina B.; Wen, Xia; Cunningham, Danielle; Tarantino, Lisa M.; Wiltshire, Tim; Gauthier, Josée; Tohyama, Sarasa; Martin, Loren J.; Mogil, Jeffrey S.; Diatchenko, Luda Less PAIN. 156(10):1965-1977, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: A functional mouse Comt allele, associated with pain behaviour, increases Comt expression by inserting an early polyadenylation signal and removing naturally occurring regulatory microRNA signals. Buy SDC
The Experience of Cognitive Intrusion of Pain: scale development and validation Attridge, Nina; Crombez, Geert; Van Ryckeghem, Dimitri; More Attridge, Nina; Crombez, Geert; Van Ryckeghem, Dimitri; Keogh, Edmund; Eccleston, Christopher Less PAIN. 156(10):1978-1990, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The Experience of Cognitive Intrusion of Pain scale was unidimensional, showed construct validity, differentiated fibromyalgia patients and controls, and predicted pain disability. Buy
Overactivity in chronic pain: is it a valid construct? Andrews, Nicole Emma; Strong, Jenny; Meredith, Pamela Joy Andrews, Nicole Emma; Strong, Jenny; Meredith, Pamela Joy Less PAIN. 156(10):1991-2000, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Findings from a 5-day observation study link high levels of self-reported overactivity to repeated periods of prolonged activity engagement followed by significant pain increases. Buy
Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain La Porta, Carmen; Bura, S. Andreea; Llorente-Onaindia, Jone; More La Porta, Carmen; Bura, S. Andreea; Llorente-Onaindia, Jone; Pastor, Antoni; Navarrete, Francisco; García-Gutiérrez, María Salud; De la Torre, Rafael; Manzanares, Jorge; Monfort, Jordi; Maldonado, Rafael Less PAIN. 156(10):2001-2012, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: CB1R and CB2R differentially modulate the affective manifestations but not the cognitive impairment associated with osteoarthritis pain. Buy SDC
A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain Ziegler, Dan; Duan, W. Rachel; An, Guohua; More Ziegler, Dan; Duan, W. Rachel; An, Guohua; Thomas, James W.; Nothaft, Wolfram Less PAIN. 156(10):2013-2020, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Treatment with ABT-639 100 mg for 6 weeks did not significantly reduce pain in patients with diabetic peripheral neuropathy. Buy SDC
Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic–pituitary–adrenal axis output in female mice Pierce, Angela N.; Zhang, Zhen; Fuentes, Isabella M.; More Pierce, Angela N.; Zhang, Zhen; Fuentes, Isabella M.; Wang, Ruipeng; Ryals, Janelle M.; Christianson, Julie A. Less PAIN. 156(10):2021-2031, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Neonatal irritation of the vagina permanently sensitizes the vagina and distant somatic structures in a corticotrophin-releasing factor-dependent manner. Buy SDC
Altered pain modulation in patients with persistent postendodontic pain Nasri-Heir, Cibele; Khan, Junad; Benoliel, Rafael; More Nasri-Heir, Cibele; Khan, Junad; Benoliel, Rafael; Feng, Changyong; Yarnitsky, David; Kuo, Fengshen; Hirschberg, Craig; Hartwell, Gary; Huang, Ching-Yu; Heir, Gary; Korczeniewska, Olga; Diehl, Scott R.; Eliav, Eli Less PAIN. 156(10):2032-2041, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Patients suffering from persistent pain after endodontic treatment have less efficient pain modulation system compared with healthy controls. Buy
Monosynaptic convergence of somatic and visceral C-fiber afferents on projection and local circuit neurons in lamina I: a substrate for referred pain Luz, Liliana L.; Fernandes, Elisabete C.; Sivado, Miklos; More Luz, Liliana L.; Fernandes, Elisabete C.; Sivado, Miklos; Kokai, Eva; Szucs, Peter; Safronov, Boris V. Less PAIN. 156(10):2042-2051, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Spinal lamina I is the first site in the central nervous system where somatic and visceral pathways monosynaptically converge onto projection and local circuit neurons. Buy
Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity D'Mello, Richard; Sand, Claire A.; Pezet, Sophie; More D'Mello, Richard; Sand, Claire A.; Pezet, Sophie; Leiper, James M.; Gaurilcikaite, Egle; McMahon, Stephen B.; Dickenson, Anthony H.; Nandi, Manasi Less PAIN. 156(10):2052-2060, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Inhibition of dimethylarginine dimethylaminohydrolase 1 attenuates pain-related behavior and hyperexcitability in pain conditions associated with excessive nitric oxide production, representing a novel therapeutic target. Buy SDC
The organisation of spinoparabrachial neurons in the mouse Cameron, Darren; Polgár, Erika; Gutierrez-Mecinas, Maria; More Cameron, Darren; Polgár, Erika; Gutierrez-Mecinas, Maria; Gomez-Lima, Maria; Watanabe, Masahiko; Todd, Andrew J. Less PAIN. 156(10):2061-2071, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: This study suggests that 5% of lamina I neurons are projection cells, which most express the neurokinin 1 receptor, and that these can generally be distinguished from interneurons based on their larger size. Go to Full Text of this Article Open
COMT gene locus: new functional variants Meloto, Carolina B.; Segall, Samantha K.; Smith, Shad; More Meloto, Carolina B.; Segall, Samantha K.; Smith, Shad; Parisien, Marc; Shabalina, Svetlana A.; Rizzatti-Barbosa, Célia M.; Gauthier, Josée; Tsao, Douglas; Convertino, Marino; Piltonen, Marjo H.; Slade, Gary Dmitri; Fillingim, Roger B.; Greenspan, Joel D.; Ohrbach, Richard; Knott, Charles; Maixner, William; Zaykin, Dmitri; Dokholyan, Nikolay V.; Reenilä, Ilkka; Männistö, Pekka T.; Diatchenko, Luda Less PAIN. 156(10):2072-2083, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: A catechol-O-methyltransferase genetic marker of pain led to the discovery of an alternative enzyme that acts through dopamine rather than epinephrine, characteristic of reference catechol-O-methyltransferase. Buy SDC
Deficits in pain perception in borderline personality disorder: results from the thermal grill illusion Bekrater-Bodmann, Robin; Chung, Boo Young; Richter, Ingmarie; More Bekrater-Bodmann, Robin; Chung, Boo Young; Richter, Ingmarie; Wicking, Manon; Foell, Jens; Mancke, Falk; Schmahl, Christian; Flor, Herta Less PAIN. 156(10):2084-2092, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The thermal grill illusion is reduced in borderline personality disorder. This suggests that the deficits in pain perception in this group are of central origin. Buy SDC
High- and low-frequency transcutaneous electrical nerve stimulation does not reduce experimental pain in elderly individuals Bergeron-Vézina, Kayla; Corriveau, Hélène; Martel, Marylie; More Bergeron-Vézina, Kayla; Corriveau, Hélène; Martel, Marylie; Harvey, Marie-Philippe; Léonard, Guillaume Less PAIN. 156(10):2093-2099, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: High- and low-frequency transcutaneous electrical nerve stimulation is effective for reducing experimental heat pain in young individuals but not in older individuals. Buy
Neuropathic pain as part of chronic widespread pain: environmental and genetic influences Momi, Sukhleen K.; Fabiane, Stella Maris; Lachance, Genevieve; More Momi, Sukhleen K.; Fabiane, Stella Maris; Lachance, Genevieve; Livshits, Gregory; Williams, Frances M. K. Less PAIN. 156(10):2100-2106, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The prevalence of neuropathic pain within chronic widespread pain is 16%. Neuropathic pain is 37% heritable and shares underlying genetic factors with chronic widespread pain. Buy SDC
Further defining and conceptualizing opioid misuse in chronic pain Voon, Pauline Voon, Pauline Less PAIN. 156(10):2107, October 2015. Favorite PDF Permissions Buy
Reply Vowles, Kevin E.; McEntee, Mindy L.; Siyahhan Julnes, Peter; More Vowles, Kevin E.; McEntee, Mindy L.; Siyahhan Julnes, Peter; Frohe, Tessa; Ney, John P.; van der Goes, David N. Less PAIN. 156(10):2107-2108, October 2015. Favorite PDF Permissions Buy
Respondent learning in chronic pain: how precise is imprecision? Fuchs, Xaver; Becker, Susanne; Kleinböhl, Dieter; More Fuchs, Xaver; Becker, Susanne; Kleinböhl, Dieter; Diers, Martin; Flor, Herta Less PAIN. 156(10):2108-2109, October 2015. Favorite PDF Permissions Buy
Reply Moseley, G. Lorimer; Vlaeyen, Johan Moseley, G. Lorimer; Vlaeyen, Johan Less PAIN. 156(10):2109-2110, October 2015. Favorite PDF Permissions Buy
Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic–pituitary–adrenal axis output in female mice Creator: Pierce, Angela N.; Zhang, Zhen; Fuentes, Isabella M.; Wang, Ruipeng; Ryals, Janelle M.; Christianson, Julie A. Duration: 3:36 PAIN October 2015, Volume 156, Issue 10; Show More Show Less Experiencing early life stress or injury increases a woman's likelihood of developing vulvodynia and concomitant dysregulation of the HPA axis. Play Favorite
