Most Popular Videos : PAIN

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Most Popular Videos

Creator: Erin Morrissey & Marco Loggia
Duration: 4:57
We used magnetic resonance spectroscopy to measure alterations in brain metabolites in patients with chronic knee pain due to knee osteoarthritis. Changes in neurometabolites were observed before and after total knee replacement, and differences observed between KOA patients and controls. Findings suggest that central nervous system alterations, including the role of glial cell activation and neuroinflammation, contribute to the pathophysiology of knee osteoarthritis.
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Creator: Jamie Rhudy & Joanna Shadlow
Duration: 5:08
This video provides a brief summary of the research presented in the PAIN article “Psychosocial and cardiometabolic predictors of chronic pain onset in Native Americans: Serial mediation analyses of 2-year prospective data from the Oklahoma Study of Native American Pain Risk”.
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Creator: Matthew C. Enkema
Duration: 3:47
This video describes findings from an investigation of the prevalence of pain and cannabis use among veterans and non-veterans. The study also explored associations between cannabis use and physical health and mental health among veterans with pain. Findings indicated that frequent cannabis use was more prevalent among veterans reporting recent paint than those not reporting pain. Also, the prevalence of cannabis use disorder was greater among veterans with pain who resided in states with medical cannabis laws than among those who did not report pain. Finally, cannabis use was not associated with physical health or mental health, which suggests that cannabis may not improve functioning.
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Creator: Angel Torrado-Carvajal, PhD and Marco L Loggia, PhD
Duration: 4:49
Video abstract of the paper published in Pain by Torrado-Carvajal et al., titled “Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain”. Narrated by Angel Torrado-Carvajal, PhD and Marco L Loggia, PhD
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Creator: Novartis Pharma AG, Basel, Switzerland
Duration: 4:23
This is a combined report of two prematurely terminated phase 2b placebo controlled randomised double blind parallel group multicentre clinical trials of EMA401, an angiotensin II type 2 receptor antagonist, in peripheral neuropathic pain.
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Creator: Inge Timmers, PhD
Duration: 4:11
In this resting-state fMRI study, Timmers and colleagues show that left amygdala resting-state functional connectivity with inferior parietal lobe was altered in youth with chronic pain, and mediated the association between catastrophizing (negative threat appraisals; predicting poorer functioning) and threat-safety discrimination learning (critical to flexibly adapt to new and changing environments). The findings provide a putative model for understanding brain circuitry giving rise to core psychological processes that cut across affective diagnoses, including persistent pain, and are relevant for their etiology.
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Creator: Kennedy, Donna L.; Kemp, Harriet I.; Ridout, Deborah; Yarnitsky, David; Rice, Andrew S.C.
Duration: 5:00
A systematic literature review was undertaken to determine if conditioned pain modulation (CPM) is reliable. Conditioned pain modulation is a reliable measure; however, the degree of reliability is heavily dependent on stimulation parameters and study methodology and this warrants consideration for investigators. The validation of CPM as a robust prognostic factor in experimental and clinical pain studies may be facilitated by improvements in the reporting of CPM reliability studies.
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Creator: Gilberto Vega, Biocommunications, University of Arizona
Duration: 4:14
This video highlights the work of Larsen et al. at the University of Arizona. In this study published in PAIN, we identified TMEM184B as important for murine itch responses to the eczema-linked cytokine IL-31. TMEM184B does this by controlling expression of key developmental pathways leading to proper receptor expression in dorsal root ganglion neurons.
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Creator: Karolina Werynska
Duration: 7:32
Werynska et al describe the phenotype of a phospho-deficient glycine receptor point mutated mouse. They use electrophysiology and mouse models of hyperalgesia to show that a single aminoacid exchange in a strong consensus site for protein kinase A-dependent phosphorylation in the glycine receptor subunit a3 strongly diminishes inflammatory hyperalgesia but has no impact on neuropathic hyperalgesia following peripheral nerve injury.
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Creator: Choopong Luansritisakul
Duration: 4:42

This is a video abstract of manuscript ID: PAIN-D-20-01162R1 (Title: Comparing the ICD-11 chronic pain classification with ICD-10: How can the new coding system make chronic pain visible? a study in a tertiary care pain clinic setting).

In this video, we explained why we decided to conduct our research and described the objective of the study. Then, the methods and the key findings were summarized. Finally, we provided the conclusions and implications of our study.

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Creator: Shanni Yamaki, David McKemy
Duration: 6:33
n mice, TRPA1 channel activation produces a sexually dimorphic neurogenic response, ultimately inducing cold pain dependent on the neurotrophin receptor GFRa3 signaling upstream of TRPM8 channels.
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Creator: Kenneth Childres, Senior Video Producer, University of Arkansas for Medical Sciences (UAMS)
Duration: 4:54
Drs. Corey Hayes and Bradley Martin present the findings of their study which examined the influence of escalating opioid doses on pain intensity among a cohort of Veterans with chronic pain. This observational study compared over 19,000 chronic opioid users that increased their opioid dose by at least 20% to an equivalent number of propensity matched persons who maintained their opioid doses and found that opioid dose escalation was not associated with improvements in NRS pain scores. These findings suggest that when contemplating whether to escalate opioid doses, the decision making process should center less on the potential benefit to improve pain intensity and more on the balance of other potential benefits and harms
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Creator: Sarah Eidbo
Duration: 3:48
This video is a short presentation on the publication, Declines and Regional Variation in Opioid Distribution by US Hospitals, detailing the methods, results, and main conclusions of the study. The study used ARCOS data from the DEA to analyze hospital opioid distribution trends and to demonstrate a decreased distribution of 12 out of 13 opioids reported on between the years of 2000 and 2019.
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Creator: Rice, Andrew S.C.; Smith, Blair H.; Blyth, Fiona M.
Duration: 4:38
In this article, we summarise, interpret, and contextualise the key aspects of the Global Burden of Disease Study 2013 pertaining to pain, which was recently published in the Lancet. It comprises a comprehensive and extensive assessment of the global burden of disease down to country level.
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Creator: Tonya M Palermo and Rocio de la Vega
Duration: 4:39
This video describes a hybrid effectiveness-implementation randomized controlled trial (RCT) of a digital health psychological intervention for pediatric chronic pain (WebMAP Mobile). The authors are Tonya Palermo, Rocio de la Vega, Caitlin Murray, Emily Law, and Chuan Zhou. This innovative trial used a stepped wedge cluster RCT design with 8 clinics in the U.S., recruiting 143 youth with chronic pain (ages 10 to 17 years). Effectiveness outcomes included pain intensity, disability, and global impression of change, while Reach, Adoption, Implementation, and Maintenance were implementation outcomes. Findings demonstrated successful implementation but effectiveness was limited by modest treatment engagement.
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Creator: Jon Brooks, Rob Gregory & Tony Pickering
Duration: 10:26
Fibromyalgia is a prevalent pain condition that is associated with cognitive impairments including in attention, memory, and executive processing. It has been proposed that fibromyalgia may be caused by altered central pain processing characterised by a loss of endogenous pain modulation. We tested whether attentional analgesia, where cognitive engagement diminishes pain percept, was attenuated in fibromyalgia patientscompared to matched healthy controls. An individually calibrated, attentional analgesia paradigm with a 2x2 block design was used with brain and brainstem-focussed fMRI. Fibromyalgia patients had both lower heat pain thresholds and speeds in a visual attention task. When this was taken into account for both attentional task and thermal stimulation, then both groups exhibited an equivalent degree of attentional analgesia. fMRI analysis showed similar patterns of activation in the main effects of pain and attention in the brain and brainstem (with the sole exceptions of increased activation in the control group in frontopolar cortex and the ipsilateral locus coeruleus). The attentional analgesic effect correlated with activity in the periaqueductal grey and rostroventromedial medulla. These findings indicate that fibromyalgia patients can engage the descending pain modulatory system if the attentional task and noxious stimulus intensity is appropriately titrated.
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Creator:
Duration: 3:58
Sensory profiles can help characterize phenotypes of neuropathy and neuropathic pain, however, the effect of pain on sensory profiles is unknown. Here, we investigate a cohort of 443 patients with painless and painful neuropathy for differences in sensation as well as self-assessed sensitivity, catastrophizing, anxiety and depression.
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