Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement Creator: Erin Morrissey & Marco Loggia Duration: 4:57 PAIN April 2021, Volume 162, Issue 4; Show More Show Less We used magnetic resonance spectroscopy to measure alterations in brain metabolites in patients with chronic knee pain due to knee osteoarthritis. Changes in neurometabolites were observed before and after total knee replacement, and differences observed between KOA patients and controls. Findings suggest that central nervous system alterations, including the role of glial cell activation and neuroinflammation, contribute to the pathophysiology of knee osteoarthritis. Play Favorite
Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis - A randomized, double-blind placebo-controlled trial Creator: Jonathan Vela Duration: 4:34 PAIN June 2022, Volume 163, Issue 6; Play Favorite
Psychosocial and cardiometabolic predictors of chronic pain onset in Native Americans: Serial mediation analyses of 2-year prospective data from the Oklahoma Study of Native American Pain Risk Creator: Jamie Rhudy & Joanna Shadlow Duration: 5:08 PAIN May 2022, Volume 163, Issue 5; Show More Show Less This video provides a brief summary of the research presented in the PAIN article “Psychosocial and cardiometabolic predictors of chronic pain onset in Native Americans: Serial mediation analyses of 2-year prospective data from the Oklahoma Study of Native American Pain Risk”. Play Favorite
Central amygdala inflammation and chronic pain Creator: Zoë Dworsky-Fried Duration: 5:35 PAIN January 2022, Volume 163, Issue 1; Show More Show Less Dworsky-Fried Z, Faig C, Vogel H, Kerr BJ, Taylor AMW (2021) Central amygdala, chronic pain, central inflammation, autoimmune-associated pain, multiple sclerosis Play Favorite
A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain Creator: Duration: 7:07 PAIN May 2022, Volume 163, Issue 5; Show More Show Less We present the molecular and neurobiological basis of prolotherapy in a mouse model of chronic muscle pain. We conclude that dextrose-mediated analgesia is volume- and ASIC1a-dependent and required the release of substance P from muscle afferents. Play Favorite
Neural and behavioral correlates of human pain avoidance in participants with and without episodic migraine Creator: Wiebke Gandhi Duration: 7:12 PAIN June 2022, Volume 163, Issue 6; Show More Show Less In this video, I briefly explain why we investigated motivational aspects of human pain avoidance and their neural underpinnings. I further go through the main findings of the study and what we conclude from them. Play Favorite
Pain, cannabis use, physical health and mental health indicators among veterans and non-veterans: Results from NESARC-III Creator: Matthew C. Enkema Duration: 3:47 PAIN February 2022, Volume 163, Issue 2; Show More Show Less This video describes findings from an investigation of the prevalence of pain and cannabis use among veterans and non-veterans. The study also explored associations between cannabis use and physical health and mental health among veterans with pain. Findings indicated that frequent cannabis use was more prevalent among veterans reporting recent paint than those not reporting pain. Also, the prevalence of cannabis use disorder was greater among veterans with pain who resided in states with medical cannabis laws than among those who did not report pain. Finally, cannabis use was not associated with physical health or mental health, which suggests that cannabis may not improve functioning. Play Favorite
Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain Creator: Angel Torrado-Carvajal, PhD and Marco L Loggia, PhD Duration: 4:49 PAIN July 2021, Volume 162, Issue 7; Show More Show Less Video abstract of the paper published in Pain by Torrado-Carvajal et al., titled “Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain”. Narrated by Angel Torrado-Carvajal, PhD and Marco L Loggia, PhD Play Favorite
Efficacy and safety of EMA401 in peripheral neuropathic pain: Results of two randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy Creator: Novartis Pharma AG, Basel, Switzerland Duration: 4:23 PAIN January 2021, Volume 162, Issue 1; Show More Show Less This is a combined report of two prematurely terminated phase 2b placebo controlled randomised double blind parallel group multicentre clinical trials of EMA401, an angiotensin II type 2 receptor antagonist, in peripheral neuropathic pain. Play Favorite
Video: Evidence-based psychological interventions for adults with chronic pain: precision, control, quality, and equipoise Creator: Amanda C de C Williams, Emma Fisher, Leslie Hearn, Christopher Eccleston Duration: 5:40 PAIN August 2021, Volume 162, Issue 8; Show More Show Less Video by authors of Topical Review: Evidence-based psychological interventions for adults with chronic pain: precision, control, quality, and equipoise Play Favorite
Quantitative language features identify placebo responders in chronic back pain Creator: Duration: 5:04 PAIN June 2021, Volume 162, Issue 6; Show More Show Less This video summarizes the paper entitled “Quantitative language features identify placebo responders in chronic back pain”, published in PAIN. Play Favorite
Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain Creator: Inge Timmers, PhD Duration: 4:11 PAIN April 2022, Volume 163, Issue 4; Show More Show Less In this resting-state fMRI study, Timmers and colleagues show that left amygdala resting-state functional connectivity with inferior parietal lobe was altered in youth with chronic pain, and mediated the association between catastrophizing (negative threat appraisals; predicting poorer functioning) and threat-safety discrimination learning (critical to flexibly adapt to new and changing environments). The findings provide a putative model for understanding brain circuitry giving rise to core psychological processes that cut across affective diagnoses, including persistent pain, and are relevant for their etiology. Play Favorite
Reliability of conditioned pain modulation: a systematic review Creator: Kennedy, Donna L.; Kemp, Harriet I.; Ridout, Deborah; Yarnitsky, David; Rice, Andrew S.C. Duration: 5:00 PAIN PAIN. 157(11):2410-2419, November 2016 Show More Show Less A systematic literature review was undertaken to determine if conditioned pain modulation (CPM) is reliable. Conditioned pain modulation is a reliable measure; however, the degree of reliability is heavily dependent on stimulation parameters and study methodology and this warrants consideration for investigators. The validation of CPM as a robust prognostic factor in experimental and clinical pain studies may be facilitated by improvements in the reporting of CPM reliability studies. Play Favorite
TMEM184B is Necessary for IL-31-Induced Itch Creator: Gilberto Vega, Biocommunications, University of Arizona Duration: 4:14 PAIN May 2022, Volume 163, Issue 5; Show More Show Less This video highlights the work of Larsen et al. at the University of Arizona. In this study published in PAIN, we identified TMEM184B as important for murine itch responses to the eczema-linked cytokine IL-31. TMEM184B does this by controlling expression of key developmental pathways leading to proper receptor expression in dorsal root ganglion neurons. Play Favorite
Loss of inflammatory hyperalgesia in a phospho-deficient glycine receptor mouse mutant Creator: Karolina Werynska Duration: 7:32 PAIN September 2021, Volume 162, Issue 9; Show More Show Less Werynska et al describe the phenotype of a phospho-deficient glycine receptor point mutated mouse. They use electrophysiology and mouse models of hyperalgesia to show that a single aminoacid exchange in a strong consensus site for protein kinase A-dependent phosphorylation in the glycine receptor subunit a3 strongly diminishes inflammatory hyperalgesia but has no impact on neuropathic hyperalgesia following peripheral nerve injury. Play Favorite
Comparing the ICD-11 chronic pain classification with ICD-10: How can the new coding system make chronic pain visible? Creator: Choopong Luansritisakul Duration: 4:42 PAIN July 2021, Volume 162, Issue 7; Show More Show Less This is a video abstract of manuscript ID: PAIN-D-20-01162R1 (Title: Comparing the ICD-11 chronic pain classification with ICD-10: How can the new coding system make chronic pain visible? a study in a tertiary care pain clinic setting). In this video, we explained why we decided to conduct our research and described the objective of the study. Then, the methods and the key findings were summarized. Finally, we provided the conclusions and implications of our study. Play Favorite
Neuronal/Astrocytic Expression of Chemokine (C-C motif) Ligand 2 is Associated with Monocyte/Macrophage Recruitment in Male Chronic Pelvic Pain. Creator: Praveen Thumbikat Duration: 5:23 PAIN November 2020, Volume 161, Issue 11; Show More Show Less Neuroimmune mechanisms in chronic pelvic pain syndrome. The role of CCL2 and macrophages in mediating neuroinflammation Play Favorite
Nociceptive afferent phenotyping reveals that TRPA1 promotes cold pain via neurogenic inflammation upstream of the neurotrophic factor receptor GFRa3 and the menthol receptor TRPM8 Creator: Shanni Yamaki, David McKemy Duration: 6:33 PAIN February 2021, Volume 162, Issue 2; Show More Show Less n mice, TRPA1 channel activation produces a sexually dimorphic neurogenic response, ultimately inducing cold pain dependent on the neurotrophin receptor GFRa3 signaling upstream of TRPM8 channels. Play Favorite
Impact of Opioid Dose Escalation on Pain Intensity: A Retrospective Cohort Study Creator: Kenneth Childres, Senior Video Producer, University of Arkansas for Medical Sciences (UAMS) Duration: 4:54 PAIN May 2020, Volume 161, Issue 5; Show More Show Less Drs. Corey Hayes and Bradley Martin present the findings of their study which examined the influence of escalating opioid doses on pain intensity among a cohort of Veterans with chronic pain. This observational study compared over 19,000 chronic opioid users that increased their opioid dose by at least 20% to an equivalent number of propensity matched persons who maintained their opioid doses and found that opioid dose escalation was not associated with improvements in NRS pain scores. These findings suggest that when contemplating whether to escalate opioid doses, the decision making process should center less on the potential benefit to improve pain intensity and more on the balance of other potential benefits and harms Play Favorite
Pain assessment in context: a state of the science review of the McGill pain questionnaire 40 years on Creator: Chris J. Main Duration: 4:13 PAIN PAIN. 157(7):1387-1399, July 2016 Show More Show Less Pain assessment in context: a state of the science review of the McGill pain questionnaire 40 years on Play Favorite
Mechanistic pain profiling in young adolescents with patellofemoral pain before and following treatment. Creator: Sinead Holden Duration: 3:16 PAIN May 2020, Volume 161, Issue 5; Show More Show Less This video describes our prospective cohort study in adolescent with knee pain. Quantitative sensory testing was completed before during and following treatment for their pain Play Favorite
Declines and Regional Variation in Opioid Distribution by US Hospitals Creator: Sarah Eidbo Duration: 3:48 PAIN June 2022, Volume 163, Issue 6; Show More Show Less This video is a short presentation on the publication, Declines and Regional Variation in Opioid Distribution by US Hospitals, detailing the methods, results, and main conclusions of the study. The study used ARCOS data from the DEA to analyze hospital opioid distribution trends and to demonstrate a decreased distribution of 12 out of 13 opioids reported on between the years of 2000 and 2019. Play Favorite
METTL3 CONTRIBUTES TO INFLAMMATORY PAIN VIA TARGETING TET1 IN YTHDF2-DEPENDENT MANNER Creator: Video creator: Jun-Li Cao, Zhiqiang Pan, Lang Rong and Qi Zhang Duration: 2:25 PAIN July 2021, Volume 162, Issue 7; Show More Show Less The molecular mechanism of RNA methyltransferase Mettl3 regulating inflammation pain. Play Favorite
Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis Creator: Ivanusic et al. Duration: 3:59 PAIN February 2022, Volume 163, Issue 2; Play Favorite
Chronic primary pain in the COVID-19 pandemic: how uncertainty and stress impact on functioning and sufferin Creator: Ann Meulders Duration: 4:22 PAIN April 2022, Volume 163, Issue 4; Play Favorite
Pain and the global burden of disease Creator: Rice, Andrew S.C.; Smith, Blair H.; Blyth, Fiona M. Duration: 4:38 PAIN PAIN. 157(4):791-796, April 2016 Show More Show Less In this article, we summarise, interpret, and contextualise the key aspects of the Global Burden of Disease Study 2013 pertaining to pain, which was recently published in the Lancet. It comprises a comprehensive and extensive assessment of the global burden of disease down to country level. Play Favorite
Interleukin-10 signaling to sensory neurons is required for resolution of chemotherapy-induced peripheral neuropathy Creator: Annemieke Kavelaars, Ph.D. Duration: 3:43 PAIN October 2020, Volume 161, Issue 10; Show More Show Less Summary of the manuscript “Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability” By Geoffroy Laumet et al. that is published in Pain and has been chosen as an Editor’s Choice article. Play Favorite
PERSPECTIVES ON: PAIN REGISTRIES Creator: Gary J Macfarlane Duration: 2:51 PAIN PAIN. 162(8):2201-2203, August 2021 Show More Show Less Discusses aspects of pain registries including design and analysis and introduces the formation of the IASP PAIN SIG Play Favorite
A digital health psychological intervention (WebMAP Mobile) for children and adolescents with chronic pain: results of a hybrid effectiveness-implementation stepped wedge cluster randomized controlled trial Creator: Tonya M Palermo and Rocio de la Vega Duration: 4:39 PAIN December 2020, Volume 161, Issue 12; Show More Show Less This video describes a hybrid effectiveness-implementation randomized controlled trial (RCT) of a digital health psychological intervention for pediatric chronic pain (WebMAP Mobile). The authors are Tonya Palermo, Rocio de la Vega, Caitlin Murray, Emily Law, and Chuan Zhou. This innovative trial used a stepped wedge cluster RCT design with 8 clinics in the U.S., recruiting 143 youth with chronic pain (ages 10 to 17 years). Effectiveness outcomes included pain intensity, disability, and global impression of change, while Reach, Adoption, Implementation, and Maintenance were implementation outcomes. Findings demonstrated successful implementation but effectiveness was limited by modest treatment engagement. Play Favorite
Central pain modulatory mechanisms of attentional analgesia are preserved in Fibromyalgia Creator: Jon Brooks, Rob Gregory & Tony Pickering Duration: 10:26 PAIN January 2022, Volume 163, Issue 1; Show More Show Less Fibromyalgia is a prevalent pain condition that is associated with cognitive impairments including in attention, memory, and executive processing. It has been proposed that fibromyalgia may be caused by altered central pain processing characterised by a loss of endogenous pain modulation. We tested whether attentional analgesia, where cognitive engagement diminishes pain percept, was attenuated in fibromyalgia patientscompared to matched healthy controls. An individually calibrated, attentional analgesia paradigm with a 2x2 block design was used with brain and brainstem-focussed fMRI. Fibromyalgia patients had both lower heat pain thresholds and speeds in a visual attention task. When this was taken into account for both attentional task and thermal stimulation, then both groups exhibited an equivalent degree of attentional analgesia. fMRI analysis showed similar patterns of activation in the main effects of pain and attention in the brain and brainstem (with the sole exceptions of increased activation in the control group in frontopolar cortex and the ipsilateral locus coeruleus). The attentional analgesic effect correlated with activity in the periaqueductal grey and rostroventromedial medulla. These findings indicate that fibromyalgia patients can engage the descending pain modulatory system if the attentional task and noxious stimulus intensity is appropriately titrated. Play Favorite
Clinical criteria and grading system for chronic nociplastic pain affecting the musculoskeletal system Creator: Eva Kosek, Chair of the IASP Terminology Task Forc Duration: 5:02 PAIN November 2021, Volume 162, Issue 11; Show More Show Less Presentation of the clinical criteria and the grading system for nociplastic pain affecting the musculoskeletal system. The critera were developed by the IASP Terminology Task Force. Play Favorite
Sensory Profiles and Self-Assessed Sensitivity and Catastrophizing of Painless and Painful Neuropathy Creator: Duration: 3:58 PAIN March 2022, Volume 163, Issue 3; Show More Show Less Sensory profiles can help characterize phenotypes of neuropathy and neuropathic pain, however, the effect of pain on sensory profiles is unknown. Here, we investigate a cohort of 443 patients with painless and painful neuropathy for differences in sensation as well as self-assessed sensitivity, catastrophizing, anxiety and depression. Play Favorite
