In Brief:
We show that resolution of chemotherapy-induced peripheral neuropathy (CIPN) after cisplatin treatment is an active process that includes a critical role for CD8+ T cells in the resolution of allodynia, spontaneous pain, numbness, and reduction of intraepidermal nerve fiber density, regardless of sex. Moreover, CD8+ T cells need to be educated by cisplatin to resolve established CIPN. We also demonstrate that cisplatin educates CD8+ T cells, which can be used to prevent CIPN induced either by cisplatin or paclitaxel.
