Ibrahim, Mohab M.; Patwardhan, Amol; Gilbraith, Kerry B.; Moutal, Aubin; Yang, Xiaofang; Chew, Lindsey A.; Largent-Milnes, Tally; Malan, T. Philip; Vanderah, Todd W.; Porreca, Frank; Khanna, Rajesh
Our findings identify the cellular and molecular basis of GLED-mediated antinociception. From a translational perspective, the discovery that GLED exposure is antinociceptive and antiallodynic, opens up routes for the development of a noninvasive therapeutic approach to pain. Consequently, modulating the duration and intensity of GLEDs may prove useful, clinically, for reducing opioid in pain management. Additionally, the long-lasting and nontolerance-inducing effects of GLEDs may improve patient compliance.