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Ethnic disparities in pain processing among healthy adults: µ-opioid receptor binding potential as a putative mechanism

Video Author: Janelle Letzen, PhD and Claudia Campbell, PhD
Published on: 05.22.2020
Associated with: April 2020, Volume 161, Issue 4;

Although ethnic differences in pain perception are well documented, the underlying mechanisms for these outcomes has not been established. The present study sought to address this knowledge gap by examining differences in µ-selective agonist binding potential (BPND; [11C]-Carfentanil) between 27 non-Hispanic Black (NHB) and 27 demographically-similar, non-Hispanic White (NHW) participants. Results suggest that NHB individuals might have generally greater unoccupied MOR density than NHW peers. Findings have implications for physiological differences underlying ethnicity-related pain disparities.

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Creator: Kenneth Childres, Senior Video Producer, University of Arkansas for Medical Sciences (UAMS)
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Drs. Corey Hayes and Bradley Martin present the findings of their study which examined the influence of escalating opioid doses on pain intensity among a cohort of Veterans with chronic pain. This observational study compared over 19,000 chronic opioid users that increased their opioid dose by at least 20% to an equivalent number of propensity matched persons who maintained their opioid doses and found that opioid dose escalation was not associated with improvements in NRS pain scores. These findings suggest that when contemplating whether to escalate opioid doses, the decision making process should center less on the potential benefit to improve pain intensity and more on the balance of other potential benefits and harms
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Creator: Janelle Letzen, PhD and Claudia Campbell, PhD
Duration: 5:34
Although ethnic differences in pain perception are well documented, the underlying mechanisms for these outcomes has not been established. The present study sought to address this knowledge gap by examining differences in µ-selective agonist binding potential (BPND; [11C]-Carfentanil) between 27 non-Hispanic Black (NHB) and 27 demographically-similar, non-Hispanic White (NHW) participants. Results suggest that NHB individuals might have generally greater unoccupied MOR density than NHW peers. Findings have implications for physiological differences underlying ethnicity-related pain disparities.
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Creator: Kenneth Childres, Senior Video Producer, University of Arkansas for Medical Sciences (UAMS)
Duration: 4:54
Drs. Corey Hayes and Bradley Martin present the findings of their study which examined the influence of escalating opioid doses on pain intensity among a cohort of Veterans with chronic pain. This observational study compared over 19,000 chronic opioid users that increased their opioid dose by at least 20% to an equivalent number of propensity matched persons who maintained their opioid doses and found that opioid dose escalation was not associated with improvements in NRS pain scores. These findings suggest that when contemplating whether to escalate opioid doses, the decision making process should center less on the potential benefit to improve pain intensity and more on the balance of other potential benefits and harms
Creator: Sophie W. Kjær
Duration: 3:39
This topical review addresses the need for considering placebo effects and including adequate control conditions in neuromodulation trials targeting chronic pain.
Creator: Rui Duarte and Sarah Nevitt
Duration: 4:46
Short overview of the article “Systematic review and meta-analysis of placebo/sham controlled randomised trials of spinal cord stimulation for neuropathic pain”
Creator: Roxann Grover
Duration: 5:25
The video talks about the study objective which was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were non-frail at baseline and highlights the findings and conclusion of the study. The findings showed that the odds ratio of becoming frail over time as a function of pain was 1.71; 95% CI: 1.41 to 2.09 after controlling for all covariates. Older age, hip fracture, high depressive symptoms, and activities of daily living disability were also associated with higher odds of becoming frail over time.
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Duration: 4:21
This video introduce a systematic review investigating neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain
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Duration: 4:03
A widespread upregulation of cortical GABA-A receptors was observed using [18F]flumazenil positron emission tomography in fibromyalgia patients, which correlated with functioning and pain.
Creator: Ballantyne, Jane C.; Sullivan, Mark D.
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Duration: 4:42
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