Carole Federico and Jonathan Kimmelman
April 2020, Volume 161, Issue 4;
Video abstract for the meta-research paper “The systematic review and meta-analysis of pregabalin preclinical studies,” authored by Carole A. Federico (McGill University), Jeffrey S. Mogil, Tim Ramsay, Dean Fergusson and Jonathan Kimmelman. Describes a research study exploring the quality and design characteristics of 531 behavioral pain studies and tests the relationship between design features and effect sizes. Pregabalin is approved by the FDA to treat a number of pain conditions, including diabetic peripheral neuropathy, postherpetic neuralgia, neuropathic pain associated with spinal cord injury and fibromyalgia. Internal validity, construct validity, external validity, publication bias and dose-response were assessed.