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Considering the potential for an increase in chronic pain following the COVID-19 pandemic

Video Author: Mary-Ann Fitzcharles
Published on: 08.13.2020

Video abstract for article: Considering the potential for an increase in chronic pain following the COVID-19 pandemic

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Creator: Mary-Ann Fitzcharles
Duration: 4:54
Video abstract for article: Considering the potential for an increase in chronic pain following the COVID-19 pandemic
Creator: Kenneth Childres, Senior Video Producer, University of Arkansas for Medical Sciences (UAMS)
Duration: 4:54
Drs. Corey Hayes and Bradley Martin present the findings of their study which examined the influence of escalating opioid doses on pain intensity among a cohort of Veterans with chronic pain. This observational study compared over 19,000 chronic opioid users that increased their opioid dose by at least 20% to an equivalent number of propensity matched persons who maintained their opioid doses and found that opioid dose escalation was not associated with improvements in NRS pain scores. These findings suggest that when contemplating whether to escalate opioid doses, the decision making process should center less on the potential benefit to improve pain intensity and more on the balance of other potential benefits and harms
Creator: Sinead Holden
Duration: 3:16
This video describes our prospective cohort study in adolescent with knee pain. Quantitative sensory testing was completed before during and following treatment for their pain
Creator: Janelle Letzen, PhD and Claudia Campbell, PhD
Duration: 5:34
Although ethnic differences in pain perception are well documented, the underlying mechanisms for these outcomes has not been established. The present study sought to address this knowledge gap by examining differences in µ-selective agonist binding potential (BPND; [11C]-Carfentanil) between 27 non-Hispanic Black (NHB) and 27 demographically-similar, non-Hispanic White (NHW) participants. Results suggest that NHB individuals might have generally greater unoccupied MOR density than NHW peers. Findings have implications for physiological differences underlying ethnicity-related pain disparities.
Creator: Carole Federico and Jonathan Kimmelman
Duration: 4:17
Video abstract for the meta-research paper “The systematic review and meta-analysis of pregabalin preclinical studies,” authored by Carole A. Federico (McGill University), Jeffrey S. Mogil, Tim Ramsay, Dean Fergusson and Jonathan Kimmelman. Describes a research study exploring the quality and design characteristics of 531 behavioral pain studies and tests the relationship between design features and effect sizes. Pregabalin is approved by the FDA to treat a number of pain conditions, including diabetic peripheral neuropathy, postherpetic neuralgia, neuropathic pain associated with spinal cord injury and fibromyalgia. Internal validity, construct validity, external validity, publication bias and dose-response were assessed.
Creator: Sophie W. Kjær
Duration: 3:39
This topical review addresses the need for considering placebo effects and including adequate control conditions in neuromodulation trials targeting chronic pain.
Creator: Eivind Hasvik
Duration: 4:31
This review examined the handling and reporting of rescue and concomitant analgesic use in 265 trials of pharmacotherapy for neuropathic pain or low back pain. Our findings suggest that poorly described procedures and incomplete reporting are likely to hinder the interpretation, critical appraisal, and replication of trial results.
Creator: Rui Duarte and Sarah Nevitt
Duration: 4:46
Short overview of the article “Systematic review and meta-analysis of placebo/sham controlled randomised trials of spinal cord stimulation for neuropathic pain”
Creator: Roxann Grover
Duration: 5:25
The video talks about the study objective which was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were non-frail at baseline and highlights the findings and conclusion of the study. The findings showed that the odds ratio of becoming frail over time as a function of pain was 1.71; 95% CI: 1.41 to 2.09 after controlling for all covariates. Older age, hip fracture, high depressive symptoms, and activities of daily living disability were also associated with higher odds of becoming frail over time.
Creator: Ina Skyt
Duration: 4:21
This video introduce a systematic review investigating neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain
Creator: Florence Pomares & Petra Schweinhardt
Duration: 4:03
A widespread upregulation of cortical GABA-A receptors was observed using [18F]flumazenil positron emission tomography in fibromyalgia patients, which correlated with functioning and pain.
Creator: Campbell, Lauren; Pillai Riddell, Rebecca; Cribbie, Robert; Garfield, Hartley; Greenberg, Saul
Duration: 2:08
This article, based on 2 companion studies, presents an in-depth analysis of preschoolers coping with vaccination pain. The research provides empirical support for the need to differentiate between coping responses and coping outcomes: 2 different, yet interrelated, components of “coping.”
Creator: Ballantyne, Jane C.; Sullivan, Mark D.
Duration: 9:39
This article explores why the endogenous opioid system is so important in terms of evolution, individual survival and day-to-day function, and how important it is to consider opioid medications within the context of these critical natural functions.
Creator: González-Hernández, Abimael; Manzano-García, Alfredo; Martínez-Lorenzana, Guadalupe; Tello-García, Irma A.a; Carranza, Martha; Arámburo, Carlos; Condés-Lara, Miguela,
Duration: 4:42
This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Taken together, our results suggest that OTRs could be found in nociceptive terminals and that on activation they are able to inhibit nociceptive input.
Creator: Steingrímsdóttir, Ólöf Anna; Landmark, Tormod; Macfarlane, Gary J; Nielsen, Christopher Sivert
Duration: 5:05
This article documents the operational definitions applied in epidemiological studies of chronic pain and to examine whether pain definitions and other methodological factors are systematically related to prevalence estimates.
Creator: Schappacher, Katie A.; Styczynski, Lauren; Baccei, Mark L.
Duration: 4:37
Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat
Creator: Klinck, Mary; Mogil, Jeffrey; Moreau, Maxim; Lascelles, Duncan; Flecknell, Paul; Poitte, Thierry; Troncy, Eric
Duration: 4:18
Translational pain assessment: could natural animal models be the missing link?
Creator: Gélinas, Céline; Puntillo, Kathleen A.; Levin, Pavel; Azoulay, Elie
Duration: 4:54
The new Behavioral Pain Assessment Tool use has shown good reliability and validity for the assessment of pain in ICU patients in 28 countries.
Creator: Martinez, Valeria; Pichard, Xavier; Fletcher, Dominique
Duration: 5:18
Updated meta-analysis including published and unpublished evidence does not support prevention of CPSP with perioperative use of pregabalin.