Nicotinic modulation of descending pain control circuitry Umana, Iboro C.; Daniele, Claire A.; Miller, Brooke A.; More Umana, Iboro C.; Daniele, Claire A.; Miller, Brooke A.; Abburi, Chandrika; Gallagher, Keith; Brown, Meghan A.; Mason, Peggy; McGehee, Daniel S. Less PAIN. 158(10):1938-1950, October 2017. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Nicotine has analgesic properties and some nicotinic drugs relieve pain as effectively as opioids. Previous studies have implicated the descending pain control pathway in nicotinic analgesia, but the underlying cellular mechanisms and receptor subtypes involved are largely unknown. Here we demonstrate that activation of a7 nicotinic receptors expressed by a subset of neurons in the periaqueductal grey can relieve tonic pain in an animal model. Understanding of the role of nicotinic receptors in pain control circuitry may lead to the development of more efficacious treatments for acute and chronic pain.