Effectiveness of placebo interventions for patients with nonspecific low back pain: a systematic review and meta-analysis Strijkers, Rob H.W.; Schreijenberg, Marco; Gerger, Heike; More Strijkers, Rob H.W.; Schreijenberg, Marco; Gerger, Heike; Koes, Bart W.; Chiarotto, Alessandro Less PAIN. 162(12):2792-2804, December 2021. Abstract Abstract Favorite PDF Permissions Buy SDC
Physical rehabilitation research and pain science Sterling, Michele; Keefe, Francis J. Sterling, Michele; Keefe, Francis J. Less PAIN. 162(11):2621-2624, November 2021. Favorite PDF Permissions Buy
Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system Kosek, Eva; Clauw, Daniel; Nijs, Jo; More Kosek, Eva; Clauw, Daniel; Nijs, Jo; Baron, Ralf; Gilron, Ian; Harris, Richard E.; Mico, Juan-Antonio; Rice, Andrew S.C.; Sterling, Michele Less PAIN. 162(11):2629-2634, November 2021. Favorite PDF Permissions Open SDC
Effect of back problems on healthcare utilization and costs in Ontario, Canada: a population-based matched cohort study Wong, Jessica J.; Côté, Pierre; Tricco, Andrea C.; More Wong, Jessica J.; Côté, Pierre; Tricco, Andrea C.; Watson, Tristan; Rosella, Laura C. Less PAIN. 162(10):2521-2531, October 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Adults with back problems had higher cause-specific and all-cause healthcare utilization and costs than those without back problems, which represents a substantial health system burden. Buy SDC
An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial Gilligan, Christopher; Volschenk, Willem; Russo, Marc; More Gilligan, Christopher; Volschenk, Willem; Russo, Marc; Green, Matthew; Gilmore, Christopher; Mehta, Vivek; Deckers, Kristiaan; De Smedt, Kris; Latif, Usman; Georgius, Peter; Gentile, Jonathan; Mitchell, Bruce; Langhorst, Meredith; Huygen, Frank; Baranidharan, Ganesan; Patel, Vikas; Mironer, Eugene; Ross, Edgar; Carayannopoulos, Alexios; Hayek, Salim; Gulve, Ashish; Van Buyten, Jean-Pierre; Tohmeh, Antoine; Fischgrund, Jeffrey; Lad, Shivanand; Ahadian, Farshad; Deer, Timothy; Klemme, William; Rauck, Richard; Rathmell, James; Levy, Robert; Heemels, Jan Pieter; Eldabe, Sam; for the ReActiv8-B investigators Less PAIN. 162(10):2486-2498, October 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Randomized, sham-controlled, double-blinded trial to demonstrate safety and efficacy of a novel, implantable restorative-neurostimulator targeting functional instability of the lumbar spine in patients with refractory mechanical chronic low back pain. Go to Full Text of this Article Open
Medical interventions have not solved the epidemic of chronic low back pain: will neurostimulation of the multifidus muscle be different? Atlas, Steven J. Atlas, Steven J. Less PAIN. 162(10):2464-2465, October 2021. Favorite PDF Permissions Buy
Genome-wide association studies of low back pain and lumbar spinal disorders using electronic health record data identify a locus associated with lumbar spinal stenosis Suri, Pradeep; Stanaway, Ian B.; Zhang, Yanfei; More Suri, Pradeep; Stanaway, Ian B.; Zhang, Yanfei; Freidin, Maxim B.; Tsepilov, Yakov A.; Carrell, David S.; Williams, Frances M.K.; Aulchenko, Yurii S.; Hakonarson, Hakon; Namjou, Bahram; Crosslin, David R.; Jarvik, Gail P.; Lee, Ming Ta Less PAIN. 162(8):2263-2272, August 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: This genome-wide association meta-analysis of lumbar spinal disorders identified and replicated a novel locus associated with lumbar spinal stenosis. Buy SDC
Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low back pain? A randomized controlled trial Bruehl, Stephen; Burns, John W.; Koltyn, Kelli; More Bruehl, Stephen; Burns, John W.; Koltyn, Kelli; Gupta, Rajnish; Buvanendran, Asokumar; Edwards, David; Chont, Melissa; Wu, Yung Hsuan; Stone, Amanda Less PAIN. 162(8):2204-2213, August 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: An aerobic exercise intervention reduced morphine efficacy in patients with chronic back pain, but also produced analgesia comparable to that observed after ≈7 mg morphine administered preintervention. Buy SDC
Examining attentional biases, interpretation biases, and attentional control in people with and without chronic pain BlaisdaleJones, Emma; Sharpe, Louise; Todd, Jemma; More BlaisdaleJones, Emma; Sharpe, Louise; Todd, Jemma; MacDougall, Hamish; Nicholas, Michael; Colagiuri, Ben Less PAIN. 162(7):2110-2119, July 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: We found that attention biases were ubiquitous, such that people attended to pain regardless of their pain status. Although we did not observe differences between those with and without CP for interpretation biases or attentional control, both interpretation bias and attentional control independently contributed variance to pain severity. Buy SDC
Classification algorithm for the International Classification of Diseases-11 chronic pain classification: development and results from a preliminary pilot evaluation Korwisi, Beatrice; Hay, Ginea; Attal, Nadine; More Korwisi, Beatrice; Hay, Ginea; Attal, Nadine; Aziz, Qasim; Bennett, Michael I.; Benoliel, Rafael; Cohen, Milton; Evers, Stefan; Giamberardino, Maria Adele; Kaasa, Stein; Kosek, Eva; Lavand'homme, Patricia; Nicholas, Michael; Perrot, Serge; Schug, Stephan; Smith, Blair H.; Svensson, Peter; Vlaeyen, Johan W.S.; Wang, Shuu-Jiun; Treede, Rolf-Detlef; Rief, Winfried; Barke, Antonia Less PAIN. 162(7):2087-2096, July 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The Classification Algorithm for Chronic Pain in International Classification of Diseases-11 is a linear decision tree that guides through the diagnostic criteria of the International Classification of Diseases-11 chronic pain classification, hence facilitating the diagnostic process. Buy SDC
Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial Flowers, Kelsey M.; Patton, Megan E.; Hruschak, Valerie J.; More Flowers, Kelsey M.; Patton, Megan E.; Hruschak, Valerie J.; Fields, Kara G.; Schwartz, Emily; Zeballos, Jose; Kang, James D.; Edwards, Rob R.; Kaptchuk, Ted J.; Schreiber, Kristin L. Less PAIN. 162(6):1828-1839, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Conditioned open-label placebo pills reduced postoperative daily opioid consumption and daily worst pain when used as an analgesic adjuvant for 2 weeks after spinal surgery. Buy SDC
Empirically derived back pain subgroups differentiated walking performance, pain, and disability Butera, Katie A.; Fox, Emily J.; Bishop, Mark D.; More Butera, Katie A.; Fox, Emily J.; Bishop, Mark D.; Coombes, Stephen A.; George, Steven Z. Less PAIN. 162(6):1806-1815, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Low back pain subgroups empirically derived from sensory, psychological, and motor measures differentiated walking performance, as well as self-reported pain intensity, pain interference, and disability. Buy
Quantitative language features identify placebo responders in chronic back pain Berger, Sara E.; Branco, Paulo; Vachon-Presseau, Etienne; More Berger, Sara E.; Branco, Paulo; Vachon-Presseau, Etienne; Abdullah, Taha B.; Cecchi, Guillermo; Apkarian, A. Vania Less PAIN. 162(6):1692-1704, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Language profiles of patients with chronic back pain can be used to identify placebo responders, as well as infer the analgesia potential of a placebo pill. Buy SDC
Developing clinical prediction models for nonrecovery in older patients seeking care for back pain: the back complaints in the elders prospective cohort study van der Gaag, Wendelien H.; Chiarotto, Alessandro; Heymans, Martijn W.; More van der Gaag, Wendelien H.; Chiarotto, Alessandro; Heymans, Martijn W.; Enthoven, Wendy T.M.; van Rijckevorsel-Scheele, Jantine; Bierma-Zeinstra, Sita M.A.; Bohnen, Arthur M.; Koes, Bart W. Less PAIN. 162(6):1632-1640, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Three clinical prediction models were developed for nonrecovery in older adults seeking care for back pain; the model predicting persistent disability performed best (optimism-adjusted R2 46%, area under the curve 0.85). Go to Full Text of this Article Open
Fear-avoidance beliefs are associated with reduced lumbar spine flexion during object lifting in pain-free adults Knechtle, Deborah; Schmid, Stefan; Suter, Magdalena; More Knechtle, Deborah; Schmid, Stefan; Suter, Magdalena; Riner, Fabienne; Moschini, Greta; Senteler, Marco; Schweinhardt, Petra; Meier, Michael L. Less PAIN. 162(6):1621-1631, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Pain-related fear is associated with less lumbar flexion during lifting in pain-free adults, indicating a protective movement strategy in the absence of low back pain. Go to Full Text of this Article Open
Photobiomodulation therapy is not better than placebo in patients with chronic nonspecific low back pain: a randomised placebo-controlled trial Guimarães, Layana de Souza; Costa, Lucíola da Cunha Menezes; Araujo, Amanda Costa; More Guimarães, Layana de Souza; Costa, Lucíola da Cunha Menezes; Araujo, Amanda Costa; Nascimento, Dafne Port; Medeiros, Flávia Cordeiro; Avanzi, Marina Athayde; Leal-Junior, Ernesto Cesar Pinto; Costa, Leonardo Oliveira Pena; Tomazoni, Shaiane Silva Less PAIN. 162(6):1612-1620, June 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: This clinical trial demonstrated that photobiomodulation therapy was not better than placebo in patients with chronic nonspecific back pain. Buy
Photobiomodulation therapy for chronic low back pain: time to move on Maher, Christopher G. Maher, Christopher G. Less PAIN. 162(6):1589-1590, June 2021. Favorite PDF Permissions Buy
Open-label placebo for chronic low back pain: a 5-year follow-up Carvalho, Claudia; Pais, Maria; Cunha, Lidia; More Carvalho, Claudia; Pais, Maria; Cunha, Lidia; Rebouta, Paula; Kaptchuk, Ted J.; Kirsch, Irving Less PAIN. 162(5):1521-1527, May 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Patients maintained their significant reductions in pain and disability and substantially decreased their medication use 5 years after having received open-label placebos for 3 weeks. Buy
Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women Reckziegel, Diane; Abdullah, Taha; Wu, Binbin; More Reckziegel, Diane; Abdullah, Taha; Wu, Binbin; Wu, Bo; Huang, Lejian; Schnitzer, Thomas J.; Apkarian, A. Vania Less PAIN. 162(5):1457-1467, May 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The left anterior hippocampus undergoes outward deformation in women with chronic back pain. The finding seems to generalize across studies, ethnicities, image acquisition parameters, and hardware. Buy
Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain Torrado-Carvajal, Angel; Toschi, Nicola; Albrecht, Daniel S.; More Torrado-Carvajal, Angel; Toschi, Nicola; Albrecht, Daniel S.; Chang, Ken; Akeju, Oluwaseun; Kim, Minhae; Edwards, Robert R.; Zhang, Yi; Hooker, Jacob M.; Duggento, Andrea; Kalpathy-Cramer, Jayashree; Napadow, Vitaly; Loggia, Marco L. Less PAIN. 162(4):1241-1249, April 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Thalamic neuroinflammatory signal is a reproducible and discriminating feature for chronic low back pain, and contains a richness of information that the simple mean might fail to completely capture. Buy SDC
Sex- and age-specific genetic analysis of chronic back pain Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; More Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; Meng, Weihua; Hayward, Caroline; Smith, Blair H.; Khoury, Samar; Parisien, Marc; Bortsov, Andrey; Diatchenko, Luda; Børte, Sigrid; Winsvold, Bendik S.; Brumpton, Ben M.; Zwart, John-Anker; HUNT All-In Pain; Aulchenko, Yurii S.; Suri, Pradeep; Williams, Frances M.K. Less PAIN. 162(4):1176-1187, April 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Genetic factors of chronic back pain exhibit mild sex- and age-specificity. This raises the need for sex- and age-stratified analyses of chronic pain in future studies. Buy SDC
Complex sociodemographic inequalities in consultations for low back pain: lessons from multilevel intersectional analysis Kiadaliri, Ali; Merlo, Juan; Englund, Martin Kiadaliri, Ali; Merlo, Juan; Englund, Martin Less PAIN. 162(4):1135-1143, April 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: We found substantial individual heterogeneity in consultation for low back pain that could not be explained by combination of age, sex, education, income, and nativity. Go to Full Text of this Article Open SDC
Cross-sectional study of psychosocial and pain-related variables among patients with chronic pain during a time of social distancing imposed by the coronavirus disease 2019 pandemic Hruschak, Valerie; Flowers, K. Mikayla; Azizoddin, Desiree R.; More Hruschak, Valerie; Flowers, K. Mikayla; Azizoddin, Desiree R.; Jamison, Robert N.; Edwards, Robert R.; Schreiber, Kristin L. Less PAIN. 162(2):619-629, February 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Chronic pain severity and interference worsened under conditions of social distancing, with certain sociodemographic factors and high pain catastrophizing associated with greater impact. Buy SDC
High-dose spinal cord stimulation for patients with failed back surgery syndrome: a multicenter effectiveness and prediction study Goudman, Lisa; De Smedt, Ann; Eldabe, Sam; More Goudman, Lisa; De Smedt, Ann; Eldabe, Sam; Rigoard, Philippe; Linderoth, Bengt; De Jaeger, Mats; Moens, Maarten; Discover Consortium Less PAIN. 162(2):582-590, February 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: High dose spinal cord stimulation is a valid option for failed back surgery syndrome to obtain back and leg pain relief after 1 year. High-dose spinal cord stimulation also improves sleep quality, functionality, and quality of life, and reduces pain medication intake. Buy
Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex Jang, Jae-Hwan; Song, Eun-Mo; Do, Young-Ho; More Jang, Jae-Hwan; Song, Eun-Mo; Do, Young-Ho; Ahn, Sora; Oh, Ju-Young; Hwang, Tae-Yeon; Ryu, Yeonhee; Jeon, Songhee; Song, Mi-Yeon; Park, Hi-Joon Less PAIN. 162(2):514-530, February 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Acupuncture treatment for 6-month period altered DNA methylation patterns, particularly in the prefrontal cortex, in a mouse model of chronic neuropathic pain. Go to Full Text of this Article Open SDC
Attentional bias to somatosensory stimuli in chronic pain patients: a systematic review and meta-analysis Broadbent, Philippa; Liossi, Christina; Schoth, Daniel E. Broadbent, Philippa; Liossi, Christina; Schoth, Daniel E. Less PAIN. 162(2):332-352, February 2021. Abstract Abstract Favorite PDF Permissions Buy
Virtual reality approaches to pain: toward a state of the science Trost, Zina; France, Christopher; Anam, Monima; More Trost, Zina; France, Christopher; Anam, Monima; Shum, Corey Less PAIN. 162(2):325-331, February 2021. Favorite PDF Permissions Buy SDC
Assessing the validity of health administrative data compared to population health survey data for the measurement of low back pain Wong, Jessica J.; Côté, Pierre; Tricco, Andrea C.; More Wong, Jessica J.; Côté, Pierre; Tricco, Andrea C.; Watson, Tristan; Rosella, Laura C. Less PAIN. 162(1):219-226, January 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Using health administrative data to measure Low back pain underestimates low back pain prevalence among adults and can lead to misclassification bias that is likely nondifferential. Go to Full Text of this Article Open SDC
Cold pain hypersensitivity predicts trajectories of pain and disability after low back surgery: a prospective cohort study Müller, Monika; Bütikofer, Lukas; Andersen, Ole K.; More Müller, Monika; Bütikofer, Lukas; Andersen, Ole K.; Heini, Paul; Arendt-Nielsen, Lars; Jüni, Peter; Curatolo, Michele Less PAIN. 162(1):184-194, January 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Cold pain hypersensitivity was a strong predictor of pain and disability during 1 year after low back surgery. Buy SDC
Abnormal subgenual anterior cingulate circuitry is unique to women but not men with chronic pain Osborne, Natalie R.; Cheng, Joshua C.; Rogachov, Anton; More Osborne, Natalie R.; Cheng, Joshua C.; Rogachov, Anton; Kim, Junseok Andrew; Hemington, Kasey S.; Bosma, Rachael L.; Inman, Robert D.; Davis, Karen D. Less PAIN. 162(1):97-108, January 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: In chronic pain, there are sex differences and sex-specific abnormalities in the functional connectivity of the subgenual anterior cingulate cortex, a key node of the descending antinociceptive system. Buy SDC
Differential sensory and clinical phenotypes of patients with chronic widespread and regional musculoskeletal pain Finnern, Marina M.; Kleinböhl, Dieter; Flor, Herta; More Finnern, Marina M.; Kleinböhl, Dieter; Flor, Herta; Benrath, Justus; Hölzl, Rupert Less PAIN. 162(1):56-70, January 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Four sensory phenotypes of chronic primary pain differing in spatial pain patterns and comorbidity were identified by latent class analysis. This qualifies current fibromyalgia criteria. Buy SDC
Early changes in brain network topology and activation of affective pathways predict persistent pain in the rat Sperry, Megan M.; Granquist, Eric J.; Winkelstein, Beth A. Sperry, Megan M.; Granquist, Eric J.; Winkelstein, Beth A. Less PAIN. 162(1):45-55, January 2021. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Adaptations in brain networks occur early after pain onset in persistent, but not transient, jaw pain, a potential early biomarker of chronic pain conditions. Buy SDC
The predictive value of quantitative sensory testing: a systematic review on chronic postoperative pain and the analgesic effect of pharmacological therapies in patients with chronic pain Petersen, Kristian Kjær; Vaegter, Henrik B.; Stubhaug, Audun; More Petersen, Kristian Kjær; Vaegter, Henrik B.; Stubhaug, Audun; Wolff, André; Scammell, Brigitte E.; Arendt-Nielsen, Lars; Larsen, Dennis B. Less PAIN. 162(1):31-44, January 2021. Abstract Abstract Favorite PDF Permissions Buy
High-resolution, field approaches for assessing pain: Ecological Momentary Assessment Stone, Arthur A.; Obbarius, Alexander; Junghaenel, Doerte U.; More Stone, Arthur A.; Obbarius, Alexander; Junghaenel, Doerte U.; Wen, Cheng K.F.; Schneider, Stefan Less PAIN. 162(1):4-9, January 2021. Favorite PDF Permissions Open
