Cannabis for migraine treatment: the once and future prescription? An historical and scientific reviewRusso, Ethan*PAIN: May 1998 - Volume 76 - Issue 1 - p 3–8 doi: 10.1016/S0304-3959(98)00033-5 Review Article Buy SDC Abstract Author InformationAuthors Article MetricsMetrics Cannabis, or marijuana, has been used for centuries for both symptomatic and prophylactic treatment of migraine. It was highly esteemed as a headache remedy by the most prominent physicians of the age between 1874 and 1942, remaining part of the Western pharmacopoeia for this indication even into the mid-twentieth century. Current ethnobotanical and anecdotal references continue to refer to its efficacy for this malady, while biochemical studies of THC and anandamide have provided a scientific basis for such treatment. The author believes that controlled clinical trials of Cannabis in acute migraine treatment are warranted. Department of Neurology, Western Montana Clinic, 515 West Front Street, Missoula, MT 58907–7609, USA *Tel.: +1 406 3297238; fax: +1 406 3297453; e-mail: email@example.com Accepted January 26, 1998. © Lippincott-Raven Publishers.