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Neuronal/Astrocytic Expression of Chemokine (C-C motif) Ligand 2 is Associated with Monocyte/Macrophage Recruitment in Male Chronic Pelvic Pain.

Video Author: Praveen Thumbikat
Published on: 01.25.2021
Associated with: November 2020, Volume 161, Issue 11;

Neuroimmune mechanisms in chronic pelvic pain syndrome. The role of CCL2 and macrophages in mediating neuroinflammation

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Creator: Praveen Thumbikat
Duration: 5:23
Neuroimmune mechanisms in chronic pelvic pain syndrome. The role of CCL2 and macrophages in mediating neuroinflammation
Creator: Prof Stuart Brierley
Duration: 4:42
Creator: Emanuele M. Giusti, PhD
Duration: 4:39
This video presents a systematic review and meta-analysis which was undertook to assess the strength of the association between psychological predictors and chronic post-surgical pain. The results suggest that state anxiety is the psychological predictor with the highest effect size, followed by catastrophizing, depression and trait anxiety. Mental health, kinesiophobia and self-efficacy had small effect sizes and optimism was not significantly associated with chronic post-surgical pain. These results have implications for the identifications of patients at risk.
Creator: Wenbin Wu, MD. Fourth Military Medical University
Duration: 8:38
Dr. Ceng Luo and Fei Wang unraveled a peripheral target, PKG-I localized in primary afferent nociceptors, which influences central sensitization by enhancing cortical plasticity in the ACC via regulation of BDNF function after nerve injury. Developing analgesic therapeutics against peripheral PKG-I may pave the new way for treatment of neuropathic pain with least side effects.
Creator: Human Migraine Research Unit, Danish Headache Center
Duration: 2:57
Video Abstract of study titled Intradural Artery Dilation During Experimentally Induced Migraine Attacks. First author Casper Emil Christensen and last author Messoud Ashina describe the study background, findings and interpretation.
Creator: Erica Rankin and Hector Gonzalez
Duration: 3:34
SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
Creator: Gilberto Vega
Duration: 5:53
Cdk5 – a key kinase in pain signaling
Creator: Tonya M Palermo and Rocio de la Vega
Duration: 04:39
This video describes a hybrid effectiveness-implementation randomized controlled trial (RCT) of a digital health psychological intervention for pediatric chronic pain (WebMAP Mobile). The authors are Tonya Palermo, Rocio de la Vega, Caitlin Murray, Emily Law, and Chuan Zhou. This innovative trial used a stepped wedge cluster RCT design with 8 clinics in the U.S., recruiting 143 youth with chronic pain (ages 10 to 17 years). Effectiveness outcomes included pain intensity, disability, and global impression of change, while Reach, Adoption, Implementation, and Maintenance were implementation outcomes. Findings demonstrated successful implementation but effectiveness was limited by modest treatment engagement.
Creator: Kai Karos
Duration: 6:07
This video summarizes the main points made in our topical review entitled “The Social Threats of COVID-19 for People with Chronic Pain”.
Creator: Annemieke Kavelaars, Ph.D.
Duration: 3:43
Summary of the manuscript “Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability” By Geoffroy Laumet et al. that is published in Pain and has been chosen as an Editor’s Choice article.
Creator: Franziska Denk
Duration: 2:26
Authors Franzika Denk and Zoe Hore from King’s College London talk about their latest publication in Pain entitled “A transcripitional toolbox for exploring peripheral neuro-immune interactions”.
Creator: Lars J. von Buchholtz, Alexander T. Chesler and Nicholas J.P. Ryba
Duration: 4:07
Single cell sequencing has revealed new details about diversity of somatosensory neurons. Here we developed a relatively straightforward approach for classifying neurons in tissue sections. We automated the approach using a custom deep-learning algorithm. We then used the approach to explore the significance of neuronal transcriptomic class in the trigeminal system.