Transient synapses, permanent pain Martina, Marco Martina, Marco Less PAIN. 162(5):1279-1280, May 2021. Favorites PDF Get Content & Permissions Buy
Towards the endotyping of the sleep–pain interaction: a topical review on multitarget strategies based on phenotypic vulnerabilities and putative pathways Herrero Babiloni, Alberto; Beetz, Gabrielle; Tang, Nicole K.Y.; More Herrero Babiloni, Alberto; Beetz, Gabrielle; Tang, Nicole K.Y.; Heinzer, Raphael; Nijs, Jo; Martel, Marc O.; Lavigne, Gilles J. Less PAIN. 162(5):1281-1288, May 2021. Favorites PDF Get Content & Permissions Buy
Where do children learn about pain? The role of caregiver responses to preschoolers' pain experience within natural settings O'Sullivan, Grace; McGuire, Brian E.; Roche, Michelle; More O'Sullivan, Grace; McGuire, Brian E.; Roche, Michelle; Caes, Line Less PAIN. 162(5):1289-1294, May 2021. Favorites PDF Get Content & Permissions Buy
Screening and diagnostic tools for complex regional pain syndrome: a systematic review Mesaroli, Giulia; Hundert, Amos; Birnie, Kathryn A.; More Mesaroli, Giulia; Hundert, Amos; Birnie, Kathryn A.; Campbell, Fiona; Stinson, Jennifer Less PAIN. 162(5):1295-1304, May 2021. Abstract Abstract Favorites PDF Get Content & Permissions Go to Full Text of this Article Open SDC
Fabry disease pain: patient and preclinical parallels Burand, Anthony J. Jr; Stucky, Cheryl L. Burand, Anthony J. Jr; Stucky, Cheryl L. Less PAIN. 162(5):1305-1321, May 2021. Abstract Abstract Favorites PDF Get Content & Permissions Go to Full Text of this Article Open SDC
Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex Wang, Yao Q.; Wang, Junshi; Xia, Sun-hui; More Wang, Yao Q.; Wang, Junshi; Xia, Sun-hui; Gutstein, Howard B.; Huang, Yanhua H.; Schlüter, Oliver M.; Cao, Jun-Li; Dong, Yan Less PAIN. 162(5):1322-1333, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Neuropathic pain generated silent synapses within the projection from the mediodorsal thalamus to the ACC, resulting in persistent circuit remodeling and sensitized nociceptive responses. Buy
A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy Bali, Kiran Kumar; Gandla, Jagadeesh; Rangel, Daniel Rojas; More Bali, Kiran Kumar; Gandla, Jagadeesh; Rangel, Daniel Rojas; Castaldi, Laura; Mouritzen, Peter; Agarwal, Nitin; Schmelz, Martin; Heppenstall, Paul; Kuner, Rohini Less PAIN. 162(5):1334-1351, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: We identify microRNAs that are functionally associated with painful phase in diabetes through genome-wide screening, behavioral assays, cellular localization, and in silico analyses. Buy SDC
A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity Ellingsen, Dan-Mikael; Beissner, Florian; Moher Alsady, Tawfik; More Ellingsen, Dan-Mikael; Beissner, Florian; Moher Alsady, Tawfik; Lazaridou, Asimina; Paschali, Myrella; Berry, Michael; Isaro, Laura; Grahl, Arvina; Lee, Jeungchan; Wasan, Ajay D.; Edwards, Robert R.; Napadow, Vitaly Less PAIN. 162(5):1352-1363, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Using digital pain drawings and functional magnetic resonance imaging, we found a link between pain catastrophizing and pain widespreadness in fibromyalgia, which was mediated by cross-network brain connectivity. Go to Full Text of this Article Free SDC
A randomized, controlled trial of a β2-agonist in painful polyneuropathy Gillving, Mimmi; Demant, Dyveke; Holbech, Jakob V.; More Gillving, Mimmi; Demant, Dyveke; Holbech, Jakob V.; Gylfadottir, Sandra Sif; Bach, Flemming W.; Jensen, Troels S.; Finnerup, Nanna B.; Sindrup, Søren H. Less PAIN. 162(5):1364-1373, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: We found no pain-relieving effect of β2 -agonist terbutaline in patients with painful polyneuropathy. Buy
Altered trigeminal pain processing on brainstem level in persistent idiopathic facial pain Ziegeler, Christian; Schulte, Laura H.; May, Arne Ziegeler, Christian; Schulte, Laura H.; May, Arne Less PAIN. 162(5):1374-1378, May 2021. Abstract Abstract Favorites PDF Get Content & Permissions Buy
Assessing reasons for decreased primary care access for individuals on prescribed opioids: an audit study Lagisetty, Pooja; Macleod, Colin; Thomas, Jennifer; More Lagisetty, Pooja; Macleod, Colin; Thomas, Jennifer; Slat, Stephanie; Kehne, Adrianne; Heisler, Michele; Bohnert, Amy S.B.; Bohnert, Kipling M. Less PAIN. 162(5):1379-1386, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: In a multistate audit, primary care access was limited for patients taking opioids for chronic pain, and differentially further reduced when their histories suggested aberrancy. Buy SDC
Brain imaging signature of neuropathic pain phenotypes in small-fiber neuropathy: altered thalamic connectome and its associations with skin nerve degeneration Chao, Chi-Chao; Tseng, Ming-Tsung; Lin, Yea-Huey; More Chao, Chi-Chao; Tseng, Ming-Tsung; Lin, Yea-Huey; Hsieh, Paul-Chen; Lin, Chien-Ho (Janice); Huang, Shin-Leh; Hsieh, Sung-Tsang; Chiang, Ming-Chang Less PAIN. 162(5):1387-1399, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Small-fiber neuropathy is characterized by degeneration of skin nociceptive nerves. Nevertheless, reduced thalamic connectivity of pain-related regions indicated brain involvement in this disease. Buy
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice Shi, Xiaoyou; Guo, Tian-zhi; Li, Wen-wu; More Shi, Xiaoyou; Guo, Tian-zhi; Li, Wen-wu; Birklein, Frank; Escolano, Fabiola L.; Herrnberger, Myriam; Clark, J. David; Kingery, Wade S. Less PAIN. 162(5):1400-1415, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: C5a complement and cytokine signaling mediates complex regional pain syndrome patient IgM pronociceptive effects in the skin and spinal cord of fracture mice. Go to Full Text of this Article Free SDC
Cage-lid hanging behavior as a translationally relevant measure of pain in mice Zhang, Hantao; Lecker, Irene; Collymore, Chereen; More Zhang, Hantao; Lecker, Irene; Collymore, Chereen; Dokova, Anastassia; Pham, Maian Christine; Rosen, Sarah F.; Crawhall-Duk, Hayley; Zain, Maham; Valencia, Megan; Filippini, Helena Fetter; Li, Jerry; D'Souza, Abigail J.; Cho, Chulmin; Michailidis, Vassilia; Whissell, Paul D.; Patel, Ingita; Steenland, Hendrik W.; Virginia Lee, Wai-Jane; Moayedi, Massieh; Sterley, Toni-Lee; Bains, Jaideep S.; Stratton, Jo Anne; Matyas, John R.; Biernaskie, Jeff; Dubins, David; Vukobradovic, Igor; Bezginov, Alexandr; Flenniken, Ann M.; Martin, Loren J.; Mogil, Jeffrey S.; Bonin, Robert P. Less PAIN. 162(5):1416-1425, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Cage-lid hanging behavior is impaired by sustained pain in mice and can be used as an ethologically valid and translationally relevant pain outcome measure. Go to Full Text of this Article Open SDC
Characterizing chronic pain phenotypes in multiple sclerosis: a nationwide survey study Kratz, Anna L.; Whibley, Daniel; Alschuler, Kevin N.; More Kratz, Anna L.; Whibley, Daniel; Alschuler, Kevin N.; Ehde, Dawn M.; Williams, David A.; Clauw, Daniel J.; Braley, Tiffany J. Less PAIN. 162(5):1426-1433, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Chronic pain in multiple sclerosis most commonly shows characteristics consistent with nociceptive mechanisms or can be described as a mixed pain state, with characteristics of nociceptive, nociplastic, and/or neuropathic pain. Go to Full Text of this Article Open
G protein–coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion Jiang, Bao-Chun; Zhang, Jing; Wu, Bin; More Jiang, Bao-Chun; Zhang, Jing; Wu, Bin; Jiang, Ming; Cao, Hanzhong; Wu, Hao; Gao, Yong-Jing Less PAIN. 162(5):1434-1448, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: This study demonstrated that GPR151 drives trigeminal neuropathic pain through ERK-dependent chemokines expression. GPR151 may be a therapeutic target for the treatment of neuropathic pain. Buy
Headache in girls and boys growing up from age 11 to 20 years: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study Wijga, Alet H.; Gehring, Ulrike; van de Putte, Elise M.; More Wijga, Alet H.; Gehring, Ulrike; van de Putte, Elise M.; Koppelman, Gerard H.; Vader, Sarah; Schmits, Ruben J.H.; van der Wouden, Johannes C.; Picavet, H. Susan J. Less PAIN. 162(5):1449-1456, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: From age 11 to 20 years, headache prevalence hardly changed in boys, but doubled in girls, often co-occurring with other unfavorable (mental) health conditions. Go to Full Text of this Article Open SDC
Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women Reckziegel, Diane; Abdullah, Taha; Wu, Binbin; More Reckziegel, Diane; Abdullah, Taha; Wu, Binbin; Wu, Bo; Huang, Lejian; Schnitzer, Thomas J.; Apkarian, A. Vania Less PAIN. 162(5):1457-1467, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: The left anterior hippocampus undergoes outward deformation in women with chronic back pain. The finding seems to generalize across studies, ethnicities, image acquisition parameters, and hardware. Go to Full Text of this Article Free
IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia Merriwether, Ericka N.; Agalave, Nilesh M.; Dailey, Dana L.; More Merriwether, Ericka N.; Agalave, Nilesh M.; Dailey, Dana L.; Rakel, Barbara A.; Kolker, Sandra J.; Lenert, Melissa E.; Spagnola, William H.; Lu, Ying; Geasland, Katharine M.; Allen, Lee-Ann H.; Burton, Michael D.; Sluka, Kathleen A. Less PAIN. 162(5):1468-1482, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Clinical and preclinical data suggest a significant antinociceptive function of IL-5 across the peripheral nervous and immune systems in women with fibromyalgia. Buy SDC
Increase in trigeminal ganglion neurons that respond to both calcitonin gene–related peptide and pituitary adenylate cyclase–activating polypeptide in mouse models of chronic migraine and posttraumatic headache Guo, Zhaohua; Czerpaniak, Katherine; Zhang, Jintao; More Guo, Zhaohua; Czerpaniak, Katherine; Zhang, Jintao; Cao, Yu-Qing Less PAIN. 162(5):1483-1499, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The number of trigeminal ganglion neurons that respond to neuropeptides calcitonin gene–related peptide and pituitary adenylate cyclase–activating polypeptide are significantly increased in mouse models of chronic migraine and posttraumatic headache, suggesting strategies that inhibit both signaling pathways at peripheral may be more effective in preventing headache episodes than drugs that target individual pathways. Buy SDC
Intranasal delivery of an antisense oligonucleotide to the RNA-binding protein HuR relieves nerve injury-induced neuropathic pain Borgonetti, Vittoria; Galeotti, Nicoletta Borgonetti, Vittoria; Galeotti, Nicoletta Less PAIN. 162(5):1500-1510, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Intranasal anti-HuR antisense oligonucleotide, by inhibiting spinal neuroinflammation and promoting an anti-inflammatory and neuroprotectant response, might represent a noninvasive promising perspective for neuropathic pain therapy. Buy SDC
Long-term trajectories of chronic musculoskeletal pain: a 21-year prospective cohort latent class analysis Aili, Katarina; Campbell, Paul; Michaleff, Zoe A.; More Aili, Katarina; Campbell, Paul; Michaleff, Zoe A.; Strauss, Vicky Y.; Jordan, Kelvin P.; Bremander, Ann; Croft, Peter; Bergman, Stefan Less PAIN. 162(5):1511-1520, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: The trajectories identified show a long-term stability for chronic pain status for most individuals. Clinically relevant early risk factors for pain progression were identified. Go to Full Text of this Article Open SDC
Open-label placebo for chronic low back pain: a 5-year follow-up Carvalho, Claudia; Pais, Maria; Cunha, Lidia; More Carvalho, Claudia; Pais, Maria; Cunha, Lidia; Rebouta, Paula; Kaptchuk, Ted J.; Kirsch, Irving Less PAIN. 162(5):1521-1527, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Patients maintained their significant reductions in pain and disability and substantially decreased their medication use 5 years after having received open-label placebos for 3 weeks. Go to Full Text of this Article Free
Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients Gaynor, Sheila M.; Bortsov, Andrey; Bair, Eric; More Gaynor, Sheila M.; Bortsov, Andrey; Bair, Eric; Fillingim, Roger B.; Greenspan, Joel D.; Ohrbach, Richard; Diatchenko, Luda; Nackley, Andrea; Tchivileva, Inna E.; Whitehead, William; Alonso, Aurelio A.; Buchheit, Thomas E.; Boortz-Marx, Richard L.; Liedtke, Wolfgang; Park, Jongbae J.; Maixner, William; Smith, Shad B. Less PAIN. 162(5):1528-1538, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A cluster analysis method adapted for use in the clinical environment identifies groups of chronic pain patients with distinct phenotypic and prognostic profiles. Buy SDC
Predicting pain: differential pain thresholds during self-induced, externally induced, and imagined self-induced pressure pain Lalouni, Maria; Fust, Jens; Vadenmark-Lundqvist, Viktor; More Lalouni, Maria; Fust, Jens; Vadenmark-Lundqvist, Viktor; Ehrsson, H. Henrik; Kilteni, Konstantina; Birgitta Jensen, Karin Less PAIN. 162(5):1539-1544, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Imagining pressure pain to be self-induced led to increased pressure pain thresholds. Such sensory attenuation of pain was also seen in actual self-induced pressure. Go to Full Text of this Article Open SDC
Reduction in movement-evoked pain and fatigue during initial 30-minute transcutaneous electrical nerve stimulation treatment predicts transcutaneous electrical nerve stimulation responders in women with fibromyalgia Vance, Carol G.T.; Zimmerman, M. Bridget; Dailey, Dana L.; More Vance, Carol G.T.; Zimmerman, M. Bridget; Dailey, Dana L.; Rakel, Barbara A.; Geasland, Katharine M.; Chimenti, Ruth L.; Williams, Jon M.; Golchha, Meenakshi; Crofford, Leslie J.; Sluka, Kathleen A. Less PAIN. 162(5):1545-1555, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The initial transcutaneous electrical nerve stimulation response predicts response after 1 month of home use in women with fibromyalgia. Based on number needed to treat and number needed to harm, transcutaneous electrical nerve stimulation is effective and safe. Buy SDC
The effect of early procedural pain in preterm infants on the maturation of electroencephalogram and heart rate variability Lavanga, Mario; Bollen, Bieke; Caicedo, Alexander; More Lavanga, Mario; Bollen, Bieke; Caicedo, Alexander; Dereymaeker, Anneleen; Jansen, Katrien; Ortibus, Els; Van Huffel, Sabine; Naulaers, Gunnar Less PAIN. 162(5):1556-1566, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Stress exposure and early-pain procedure might increase the level of EEG and HRV dismaturity, which can ultimately impact the development outcome of the infant. Go to Full Text of this Article Open
Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives Akerman, Simon; Romero-Reyes, Marcela; Karsan, Nazia; More Akerman, Simon; Romero-Reyes, Marcela; Karsan, Nazia; Bose, Pyari; Hoffmann, Jan R.; Holland, Philip R.; Goadsby, Peter J. Less PAIN. 162(5):1567-1577, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The nitroglycerin model of migraine mediates neuronal cranial hypersensitivity and is a valid approach to predict clinical outcomes of novel abortive migraine therapeutics and study putative migraine mechanisms. Buy
Timeline of pain before dementia diagnosis: a 27-year follow-up study Kumaradev, Sushmithadev; Fayosse, Aurore; Dugravot, Aline; More Kumaradev, Sushmithadev; Fayosse, Aurore; Dugravot, Aline; Dumurgier, Julien; Roux, Christian; Kivimäki, Mika; Singh-Manoux, Archana; Sabia, Séverine Less PAIN. 162(5):1578-1585, May 2021. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: This study with repeated pain measures collected over 27 years suggests that pain is a correlate or prodromal symptom rather than a cause of dementia. Go to Full Text of this Article Open SDC
Intrathecal patient-controlled analgesia has nothing to do with breakthrough cancer pain Mercadante, Sebastiano Mercadante, Sebastiano Less PAIN. 162(5):1586, May 2021. Favorites PDF Get Content & Permissions Buy
A novel human surrogate model of noninjurious sharp mechanical pain: Erratum Less PAIN. 162(5):1587-1588, May 2021. Favorites PDF Get Content & Permissions Free
