Conceptual complexity of gender and its relevance to pain Boerner, Katelynn E.; Chambers, Christine T.; Gahagan, Jacqueline; More Boerner, Katelynn E.; Chambers, Christine T.; Gahagan, Jacqueline; Keogh, Edmund; Fillingim, Roger B.; Mogil, Jeffrey S. Less PAIN. 159(11):2137-2141, November 2018. Favorites PDF Get Content & Permissions
Depression in chronic pain Mazereeuw, Graham; Sullivan, Mark D.; Juurlink, David N. Mazereeuw, Graham; Sullivan, Mark D.; Juurlink, David N. Less PAIN. 159(11):2142-2145, November 2018. Favorites PDF Get Content & Permissions
Twenty-five years of pain education research—what have we learned? Findings from a comprehensive scoping review of research into pre-registration pain education for health professionals Thompson, Kate; Johnson, Mark I.; Milligan, James; More Thompson, Kate; Johnson, Mark I.; Milligan, James; Briggs, Michelle Less PAIN. 159(11):2146-2158, November 2018. Abstract Abstract Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article
Do post-traumatic pain and post-traumatic stress symptomatology mutually maintain each other? A systematic review of cross-lagged studies Ravn, Sophie Lykkegaard; Hartvigsen, Jan; Hansen, Maj; More Ravn, Sophie Lykkegaard; Hartvigsen, Jan; Hansen, Maj; Sterling, Michele; Andersen, Tonny Elmose Less PAIN. 159(11):2159-2169, November 2018. Abstract Abstract Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article
Involvement of lysophosphatidic acid–induced astrocyte activation underlying the maintenance of partial sciatic nerve injury–induced neuropathic pain Ueda, Hiroshi; Neyama, Hiroyuki; Nagai, Jun; More Ueda, Hiroshi; Neyama, Hiroyuki; Nagai, Jun; Matsushita, Yosuke; Tsukahara, Tamotsu; Tsukahara, Ryoko Less PAIN. 159(11):2170-2178, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: This study describes a mechanism underlying the maintenance of neuropathic pain through lysophosphatidic acid production and actions, which are mediated differentially by microglia and astrocytes. Go to Full Text of this Article
Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats Brunori, Gloria; Schoch, Jennifer; Mercatelli, Daniela; More Brunori, Gloria; Schoch, Jennifer; Mercatelli, Daniela; Ozawa, Akihiko; Toll, Lawrence; Cippitelli, Andrea Less PAIN. 159(11):2179-2191, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Tobacco smoking is prevalent in individuals experiencing chronic pain. This may be due to potent and long-lasting antiallodynic actions of nicotine in chronic pain subjects.
Location-specific responses to nociceptive input support the purposeful nature of motor adaptation to pain Gallina, Alessio; Salomoni, Sauro E.; Hall, Leanne M.; More Gallina, Alessio; Salomoni, Sauro E.; Hall, Leanne M.; Tucker, Kylie; Garland, S. Jayne; Hodges, Paul W. Less PAIN. 159(11):2192-2200, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Selective adaptation of regional muscle activation or direction of force production was induced by acute noxious stimuli applied to different tissues around the knee.
Chronic itch impairs mood and HPA axis function in mice Zhao, Xin; Yu, Chao; Ye, Feng; More Zhao, Xin; Yu, Chao; Ye, Feng; Wang, Yan-Gui; Mei, Qi-Yong; Ma, Qing; Cui, Wu-Geng; Zhou, Wen-Hua Less PAIN. 159(11):2201-2213, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Chronic itch leads to anxiety- and depression-like phenotypes in mice and impairs HPA axis function in mice. Go to Full Text of this Article
Low- and high-threshold primary afferent inputs to spinal lamina III antenna-type neurons Fernandes, Elisabete C.; Santos, Ines C.; Kokai, Eva; More Fernandes, Elisabete C.; Santos, Ines C.; Kokai, Eva; Luz, Liliana L.; Szucs, Peter; Safronov, Boris V. Less PAIN. 159(11):2214-2222, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Antenna neurons integrate low- and high-threshold primary afferent inputs and can function as wide dynamic range neurons able to directly connect deep and superficial dorsal horns.
Efficacy of adding interoceptive exposure to intensive interdisciplinary treatment for adolescents with chronic pain Flack, Florentina; Stahlschmidt, Lorin; Dobe, Michael; More Flack, Florentina; Stahlschmidt, Lorin; Dobe, Michael; Hirschfeld, Gerrit; Strasser, Alexa; Michalak, Johannes; Wager, Julia; Zernikow, Boris Less PAIN. 159(11):2223-2233, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: This randomized controlled trial showed the effectiveness of interoceptive exposure in reducing fear of pain in certain subgroups of pediatric chronic pain patients. Go to Full Text of this Article
Estimating relative efficacy in acute postoperative pain Moore, R. Andrew; Derry, Sheena; Wiffen, Philip J.; More Moore, R. Andrew; Derry, Sheena; Wiffen, Philip J.; Banerjee, Samik; Karan, Rajesh; Glimm, Ekkehard; Wiksten, Anna; Aldington, Dominic; Eccleston, Christopher Less PAIN. 159(11):2234-2244, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: There was no significant difference between network meta-analysis and simple placebo comparisons in postoperative pain using 261 trials, 39,753 patients, and 52 drug/dose combinations. Go to Full Text of this Article
Evaluation of composite responder outcomes of pain intensity and physical function in neuropathic pain clinical trials Patel, Kushang V.; Allen, Robert; Burke, Laurie; More Patel, Kushang V.; Allen, Robert; Burke, Laurie; Farrar, John T.; Gewandter, Jennifer S.; Gilron, Ian; Katz, Nathaniel P.; Markman, John D.; Marshall, Scott F.; Resnick, Malca; Rice, Andrew S.C.; Rowbotham, Michael C.; Smith, Shannon M.; Vanhove, Geertrui F.; Wasan, Ajay D.; Zhang, Shuyu; Dworkin, Robert H.; Turk, Dennis C. Less PAIN. 159(11):2245-2254, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Composite responder outcomes of pain intensity and physical function may improve the assay sensitivity and informativeness of future neuropathic pain trials.
Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors Mouchbahani-Constance, Stephanie; Lesperance, L. Stephen; Petitjean, Hugues; More Mouchbahani-Constance, Stephanie; Lesperance, L. Stephen; Petitjean, Hugues; Davidova, Albena; Macpherson, Amanda; Prescott, Steven A.; Sharif-Naeini, Reza Less PAIN. 159(11):2255-2266, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Lionfish venom causes extreme pain through unknown mechanisms. Here, we characterize the pain this venom produces and demonstrate it predominantly targets nonpeptidergic nociceptors.
Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain Bosma, Rachael L.; Kim, Junseok A.; Cheng, Joshua C.; More Bosma, Rachael L.; Kim, Junseok A.; Cheng, Joshua C.; Rogachov, Anton; Hemington, Kasey S.; Osborne, Natalie R.; Oh, Jiwon; Davis, Karen D. Less PAIN. 159(11):2267-2276, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The brain networks related to salience and pain was disrupted in patients with multiple sclerosis pain, and related to pain interference and neuropathic pain features. Go to Full Text of this Article
Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain Rodriguez-Gaztelumendi, Antonio; Spahn, Viola; Labuz, Dominika; More Rodriguez-Gaztelumendi, Antonio; Spahn, Viola; Labuz, Dominika; Machelska, Halina; Stein, Christoph Less PAIN. 159(11):2277-2284, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The newly designed, pH-dependent opioid agonist NFEPP induced analgesia exclusively through peripheral opioid receptors in models of neuropathic and abdominal pain. Go to Full Text of this Article
Anti–nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain Majuta, Lisa A.; Mitchell, Stefanie A.T.; Kuskowski, Michael A.; More Majuta, Lisa A.; Mitchell, Stefanie A.T.; Kuskowski, Michael A.; Mantyh, Patrick W. Less PAIN. 159(11):2285-2295, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Anti–nerve growth factor does not increase physical activity in young or aging naive mice but attenuates the decline in physical activity in mice with skeletal pain. Go to Full Text of this Article
Complex regional pain syndrome Drummond, Peter D.; Morellini, Natalie; Finch, Philip M.; More Drummond, Peter D.; Morellini, Natalie; Finch, Philip M.; Birklein, Frank; Knudsen, Lone F. Less PAIN. 159(11):2296-2305, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Intradermal injection of phenylephrine evoked prolonged pain and pinprick hyperalgesia in CRPS patients with histochemical signs of a1-adrenoceptor upregulation in dermal nerve bundles.
Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice Rea, Brandon J.; Wattiez, Anne-Sophie; Waite, Jayme S.; More Rea, Brandon J.; Wattiez, Anne-Sophie; Waite, Jayme S.; Castonguay, William C.; Schmidt, Chantel M.; Fairbanks, Aaron M.; Robertson, Bennett R.; Brown, Cameron J.; Mason, Bianca N.; Moldovan-Loomis, Maria-Cristina; Garcia-Martinez, Leon F.; Poolman, Pieter; Ledolter, Johannes; Kardon, Randy H.; Sowers, Levi P.; Russo, Andrew F. Less PAIN. 159(11):2306-2317, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: CGRP can induce spontaneous, nonevoked pain that is independent of light and can be measured by an objective continuous scale squint assay.
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis Hunt, James R.; Goff, Megan; Jenkins, Helen; More Hunt, James R.; Goff, Megan; Jenkins, Helen; Harris, John; Knowles, Toby G.; Lascelles, B. Duncan X.; Enomoto, Masataka; Mendl, Michael; Whay, Helen R.; Murrell, Joanna C. Less PAIN. 159(11):2318-2330, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Spinal nociceptive transmission and descending modulation were studied in dogs with spontaneous osteoarthritis. Osteoarthritis was associated with augmented reflexes and reduced descending inhibition, suggesting central sensitisation.
Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man Slimani, Hocine; Plaghki, Leon; Valenti, Paola; More Slimani, Hocine; Plaghki, Leon; Valenti, Paola; Werner, Mads U.; Kehlet, Henrik; Kupers, Ron Less PAIN. 159(11):2331-2338, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Thermal hyperalgesia following a first-degree burn injury in humans causes a sensitization of the thinly myelinated A? fibers, but not of the unmyelinated C fibers.
Neuropathic pain clinical trials Finnerup, Nanna B.; Haroutounian, Simon; Baron, Ralf; More Finnerup, Nanna B.; Haroutounian, Simon; Baron, Ralf; Dworkin, Robert H.; Gilron, Ian; Haanpaa, Maija; Jensen, Troels S.; Kamerman, Peter R.; McNicol, Ewan; Moore, Andrew; Raja, Srinivasa N.; Andersen, Niels T.; Sena, Emily S.; Smith, Blair H.; Rice, Andrew S.C.; Attal, Nadine Less PAIN. 159(11):2339-2346, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: In the past 35 years, altered study design methodology has contributed to decreases in estimated drug effect size from randomized controlled trials in neuropathic pain. Go to Full Text of this Article
Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain Odem, Max A.; Bavencoffe, Alexis G.; Cassidy, Ryan M.; More Odem, Max A.; Bavencoffe, Alexis G.; Cassidy, Ryan M.; Lopez, Elia R.; Tian, Jinbin; Dessauer, Carmen W.; Walters, Edgar T. Less PAIN. 159(11):2347-2362, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Neurophysiological specializations for generating ongoing electrical activity likely to promote ongoing pain have been defined in isolated primary nociceptors in neuropathic and inflammatory pain models. Go to Full Text of this Article
Contextual influences in decoding pain expressions Hampton, Amy J. D.; Hadjistavropoulos, Thomas; Gagnon, Michelle M. Hampton, Amy J. D.; Hadjistavropoulos, Thomas; Gagnon, Michelle M. Less PAIN. 159(11):2363-2374, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Informational primes (about pain undertreatment or social deception) interact with observer characteristics and patient age in the interpretations of pain signals. Go to Full Text of this Article
Quantifying visual allodynia across migraine subtypes Perenboom, Matthijs J.L.; Zamanipoor Najafabadi, Amir H.; Zielman, Ronald; More Perenboom, Matthijs J.L.; Zamanipoor Najafabadi, Amir H.; Zielman, Ronald; Carpay, Johannes A.; Ferrari, Michel D. Less PAIN. 159(11):2375-2382, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Visual allodynia, the burden of hypersensitivity to light and patterns, is enhanced in migraine patients, particularly in those with migraine with aura and chronic migraine. Go to Full Text of this Article
Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia Gu, Yanping; Li, Guangwen; Huang, Li-Yen Mae Gu, Yanping; Li, Guangwen; Huang, Li-Yen Mae Less PAIN. 159(11):2383-2393, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Epac–PKC signaling is essential in producing inflammation-induced potentiation of TRPV1 functions.
Prevalence of chronic pain with or without neuropathic characteristics in France using the capture–recapture method Chenaf, Chouki; Delorme, Jessica; Delage, Noémie; More Chenaf, Chouki; Delorme, Jessica; Delage, Noémie; Ardid, Denis; Eschalier, Alain; Authier, Nicolas Less PAIN. 159(11):2394-2402, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The capture–recapture method provided an updated estimation of the prevalence of chronic pain (27.2%-32.7%) and chronic neuropathic pain (5.55%-7.30%) in France. Go to Full Text of this Article
Long-term changes in biopsychosocial characteristics related to temporomandibular disorder Fillingim, Roger B.; Slade, Gary D.; Greenspan, Joel D.; More Fillingim, Roger B.; Slade, Gary D.; Greenspan, Joel D.; Dubner, Ronald; Maixner, William; Bair, Eric; Ohrbach, Richard Less PAIN. 159(11):2403-2413, November 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: In this longitudinal study, changes in temporomandibular disorder status were associated with changes in biopsychosocial characteristics among participants with and without TMD at baseline. Go to Full Text of this Article
Quantitative sensory testing in migraine patients must be phase-specific Peng, Kuan-Po; May, Arne Peng, Kuan-Po; May, Arne Less PAIN. 159(11):2414-2416, November 2018. Favorites PDF Get Content & Permissions
Reply Nahman-Averbuch, Hadas; Shefi, Tom; Schneider, Victor J. II; More Nahman-Averbuch, Hadas; Shefi, Tom; Schneider, Victor J. II; Li, Dan; Ding, Lili; King, Christopher D.; Coghill, Robert C. Less PAIN. 159(11):2416, November 2018. Favorites PDF Get Content & Permissions
