In Brief:
Musculoskeletal hyperalgesia, measured using the grip force assay in mice, can be induced by either a forced swim stress or activation of β3 adrenergic receptors and is attenuated by either prior ablation of brown adipose tissue or by elimination of UCP1 activity. Although brown adipose is typically associated with thermogenesis, brown adipose or its associated nerves may also support musculoskeletal hyperalgesia induced by stress.
