Age-standardized YLDs rate (per 100,000 persons) decreased by 24.4%, from 637.5 (95% UI: 449.9-848.8) in 1990 to 481.9 (95% UI: 338.6-637.0) in 2016 (Table 1). Beijing, Hong Kong, and Henan were the 3 highest regions of age-standardized YLDs (rates of 705.2, 540.7, and 535.6/100,000, respectively) in 2016 (supplementary Table 2, available at http://links.lww.com/PAIN/A662).
In 1990, the percent of age-standardized YLDs for LBP ranged from 5.7% to 7.9% in different provinces/regions in China, and the LBP ranked as the leading cause of YLDs in all 33 provinces/regions and in the total Chinese population at that time. However, the percent of age-standardized YLDs caused by LBP ranged from 4.3% to 7.8% in different provinces/regions and LBP ranked as the leading cause of YLDs in 16/33 provinces/regions in 2016, as the second leading cause in 8/33, as the third leading cause in 3/33, and as the fourth leading cause in 6/33 (Table 2). Therefore, LBP was the second leading cause of YLDs in the total Chinese population in 2016 (Table 2).
4.1. Characteristics of point prevalence
Many countries reported the prevalence and burden of LBP,2,6,34,37 to provide information for policy-making with regards to prevention and treatment.9 In China, only some provinces and regions reported their regional prevalence or burden of LBP.23,44 Our present study is the first systematic analysis of the point prevalence and YLDs for LBP in China from 1990 to 2016.
In 2016, the age-standardized point prevalence of LBP in China was 4.2% (95% UI: 3.8%-4.8%), which is lower than the global point prevalence of 7.0% (95% UI: 6.5%-8.1%)12,15 and similar to the China 2015 prevalence of 4.3% (95% UI: 3.8%-4.8%.10 Although the number of LBP individuals increased from 1990 to 2016, the overall point prevalence has decreased; this may contribute by the parallel with an increased total population size in China, and lifestyle changes in past decades. From the Fig. 2B, we can find that the point prevalence had significantly decreased from 2000 to 2010, Chinese population had increased income and take more care about health at that time, and the young people prefer some light labor occupations.
Beijing had the highest age-standardized point prevalence of LBP, 6.6% in 1990 and 6.2% in 2016. Tian et al.35 reported that sleeping less than 7 hours per day and “hardworking” may be the risk factors for lumbar disk disease, which may contribute to lower back pain. Beijing is a city with lights turned on all night, and with great work pressure; all these factors may keep Beijing to be the highest age-standardized point prevalence of LBP in China.
The age-standardized point prevalence of LBP in females was higher than that in males in 2016, which is consistent with many previous studies.1,27,41,42 The exact contributors for this phenomenon remain poorly understand.1 Generally, females are affected by more painful conditions of musculoskeletal system than males.25 The potential explanations of sex differences include psychological, biological, and sociocultural factors.36,41 Psychological factors of the higher sensitivity to pain among women and perceived greater willingness to report the painful symptoms may partly explain it.31,43 Biological factors of menstrual cycle fluctuations and hormonal mechanisms may also help us to explain the sex differences.30 In addition, hormonal differences and weight changes due to menopause38 and pregnancy14may also affect the musculoskeletal and neurological systems and result in LBP.
Moreover, we found the sex disparity in point prevalence to appear in the 15 to 19 age category in 1990, but delayed to the 25 to 29 age category in 2016. Previous studies reported that LBP was the most common cause of work-related disability in younger populations;1,7 therefore, may be most female participants work after primary high school in 1990, but work after college in 2016 with the improved education level, thereby delaying the onset of back pain.
For the age group more than 55 to 59 years, the sex disparity of LBP is stable, and menopause may contribute to the higher point prevalence of LBP in females42 after 50 to 55 years. It was reported that the menopause occurs at a median age of 51.3 years among the population;17 therefore, we conducted an additional stratified prevalence analysis of age group of “15 to 49” and “50 to 69” years for female population, and we found that point prevalence of “50 to 69” age group was 12.8% in 1990 and 9.7% in 2016, significantly higher than that of the “15 to 49” age group of 5.5% in 1990 and 4.8% in 2016. Lou et al.26 reported that estrogen decrease after menopause was associated with the lumbar disk degeneration, which was considered to cause the LBP; consistent results of severe intervertebral disk degeneration among postmenopausal females were found by Wang et al.39,40
4.2. Characteristics of years lived with disability
We use the YLDs to quantify the burden of LBP in this study, because there is no mortality from LBP, and years of life lost = 0. Therefore, YLDs is the same indicator to the DALYs (disability-adjusted life years), which was used by Hoy et al.22
Although the age-standardized point prevalence rate of LBP decreased from 5.6% in 1990 to 4.2% in 2016, from 1990 to 2016, the increased population size and longer life expectancy in China (the longer life expectancy in China is 69.2 years for females and 65.0 years for males, improved to 79.9 years for females and 73.4 years for males)11 contributed to the growth of YLDs. In result of above 3 mainly factors of population growth, ageing and LBP prevalence trends, the YLDs for LBP were increased 23.4%, from 6.2 million (95% UI: 4.3-8.3 million) in 1990 to 7.7 million (95% UI: 5.4-10.2) in 2016.
We also found the age category of peaked YLDs was 35 to 39 years in 1990, to delay to 45 to 49 years in 2016. One reason may be due to the longer life expectancy in 2016 than that in 1990 too (improved 10.5 years for females and 8.4 years for males).11 Another reason may be the increased number of aged population due to the baby boomers in 1960s to 1970s.19
The age-standardized YLDs rate (per 100,000 persons) was 481.9 (95% UI: 338.6-637.0) in 2016, which was lower than 788.9 (95% UI: 558.7-1034.6) as reported worldwide.12,15 Similarly, the point prevalence and age-standardized YLDs rates in 2016 decreased compared with the data from 1990 because of the larger proportional population increase than total YLDs.
The highest age-standardized YLDs rate of Beijing, Hong Kong, and Henan are 705.2, 540.7, and 535.6/100,000, respectively, in 2016, decreased from 747.9, 606.8, and 681.9/100,000, respectively, in 1990, and had decreased 5.7%, 10.9%, and 21.5%, respectively (supplementary Table 2, available at http://links.lww.com/PAIN/A662), whereas the mean decreased age-standardized YLDs rate of total China population is 24.4%. Therefore, the less decreased Beijing and Hong Kong ranked as the first and second. Henan had high basic age-standardized YLDs rate of 681.9/100,000 in 1990 and decreased 21.5%; although still ranked as the third, the value of 535.6/100,000 is very close to the top 10 provinces/regions in China (supplementary Table 2, available at http://links.lww.com/PAIN/A662).
In 1990, LBP was the first leading cause of YLDs in China, which dropped to being the second leading cause in 2016. Before this study, most hypothesized that the point prevalence and YLDs rate should continue to increase,3,22 and hence stay as the first leading cause of YLDs. However, with a greater decline in the point prevalence and YLDs, LBP became the second leading cause of YLDs in 2016. In some provinces/regions (such as Guangdong, Hubei, Shandong, Shanghai, Tianjin, and Zhejiang), LBP was even ranked as the fourth leading cause of YLDs, whereas the neck pain–caused YLDs ranked as the No.1 in above provinces/regions in 2016. Furthermore, to analyze the reasons of decreased rank of LBP-caused YLDs, we found that the prevalence of LBP in the above-mentioned provinces/regions was significantly decreased, but the point prevalence of neck pain was stable from 1990 to 2016; therefore, our data suggest that the reason of the decreased rank of LBP-caused YLDs in above-mentioned provinces/regions is the decreased prevalence of LBP, but not the increased prevalence of other diseases. Although, the reason of the decreased YLDs caused by LBP is unclear, the improvement of primary medical care and increased outdoor physical exercises in China may partly explain it.
4.3. Relevant to preventive policy
Although the point prevalence of LBP slightly decreased from 1990 to 2016, the 2016 Chinese data from the global burden study also shows that LBP is ranked as the second leading cause of YLDs burden. Therefore, governments and health care service providers should still pay considerable attention to LBP.3
Beijing reports the highest YLDs for LBP. Perhaps the experience of Guangdong, Hubei, Shandong, Shanghai, Tianjin, and Zhejiang may be helpful for Beijing to use for decreasing the point prevalence and YLDs of LBP. Having adequate rest time, less work pressure, exercises, and reducing occupational sitting time may prevent LBP.8,28,33 These are all primary care interventions that can be initiated through policy-makers. Moreover, the scarce health care resources may be allocated to the 40 to 50 age group, which reported higher YLDs for LBP, and the elderly and female population who had higher prevalence of LBP.
4.4. Strengths and limitations
In the 2016 GBD study, there were many variations in recalling period, anatomical location, and minimum duration of episodes. Such as multiple pain sites may overstated the YLDs. To ensure that the quantified LBP is more accurate than previous GBD studies, the LBP with or without activity limitations is adjusted in the 2016 GBD study (For all the data from 1990 to 2016); YLDs in this study was focused mainly caused by LBP, and use 8 sequelae to calculate the YLDs to minimize the deviation. Disability weight is another uncertainty for YLDs estimates as it is based on the selected survey, and without new data conducted since the 2013 GBD study;12,22 however, 8 DWs of health state were used in our study to minimize the deviation. Therefore, the uncertainty of DW is acceptable.
The point prevalence and YLDs rate for LBP slightly decreased from 1990 to 2016 in China. However, the total number of sufferers and YLDs remains increased. Low back pain still ranks as the second leading cause of YLDs burden in China. Considerable attention to LBP is needed, especially for the female population.
Conflict of interest statement
The authors have no conflict of interest to declare.
Author contributions: Conception and design: A. Wu, W. Dong, M. Zhou, and J. Zhao. Analysis and interpretation of data: A. Wu, W. Dong, S. Liu, X. Zeng, K. Zhang, Z. Sun, and X. Wang. Drafting the article: A. Wu, W. Dong, J.P.Y. Cheung, and K.Y.H. Kwan. Revising article critically for important intellectual content: All authors. Final approval of the version to be published: All authors.
This work was supported by the China Postdoctoral Science Foundation (2018M630450) and National Natural Science Foundation of China (81501933).
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Supplemental digital content associated with this article can be found online at http://links.lww.com/PAIN/A662.
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