^aUniversity of Toronto Medical School, Toronto, ON, Canada

^bUniversity of Washington, Seattle, WA, United States

Departments of ^cMedicine

^dPediatrics, and

^eHealth Policy, University of Toronto, Toronto, ON, Canada

Corresponding author. Address: Sunnybrook Health Sciences Centre, 075 Bayview Ave G106, Toronto, ON M4N 3M5, Canada. Tel.: (416) 480-6100; fax: (416) 480-6084. E-mail address: dnj@ices.on.ca (D.N. Juurlink).

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Received February 27, 2018

Received in revised form May 03, 2018

Accepted May 29, 2018