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Beyond nociception: the imprecision hypothesis of chronic pain

Moseley, G. Lorimera,b,*; Vlaeyen, Johan W. S.c,d

doi: 10.1016/j.pain.0000000000000014
Topical Review

The Imprecision Hypothesis: The precision with which antinociceptive multisensory information about a painful event is encoded in the brain determines the degree to which pain will generalize to similar events.

aSansom Institute for Health Research, University of South Australia, Adelaide, Australia

bNeuroscience Research Australia, Sydney, Australia

cResearch Group Health Psychology, University of Leuven, Leuven, Belgium

dDepartment of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands

Corresponding author. Address: Sansom Institute for Health Research, University of South Australia, GPO Box 2473, Adelaide 5001, Australia. Tel.: +61 (0) 8 83022454; fax: +61 (0) 8 83022853. E-mail address: (G. L. Moseley).

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Received September 11, 2014

Received in revised form October 12, 2014

Accepted October 23, 2014

© 2015 International Association for the Study of Pain
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