^aDepartment of Anesthesiology, University of Rocheser School of Medicine and Dentistry, Rochester, NY 14642, USA

^bUniversity of Washington, Seattle, WA, USA

^cUniversity of Pennsylvania, Philadelphia, PA, USA

^dJohns Hopkins University, Baltimore, MD, USA

^eHarvard University, Boston, MA, USA

^fYale University, New Haven, CT, USA

^gUniversity of Munich, Munich, Germany

^hAstraZeneca, Wilmington, DE, USA

ⁱUniversity of Queensland, Brisbane, Qld, Australia

^jTufts University, Boston, MA, USA

^kMerck & Co., Blue Bell, PA, USA

^lAmerican Chronic Pain Association, Rocklin, CA, USA

^mNational Institute of Dental and Craniofacial Research, Bethesda, MD, USA

ⁿEndo Pharmaceuticals Inc., Chadds Ford, PA, USA

^oFood and Drug Administration, Rockville, MD, USA

^pUniversity Health Network and University of Toronto, Toronto, Ont., Canada

^qPurdue Pharma, Stamford, CT, USA

^rNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA

^sPfizer Global Research and Development, Ann Arbor, MI, USA

^tNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA

^uUniversity of Rochester, Rochester, NY, USA

^vDalhousie University, Halifax, NS, Canada

^wGlaxoSmithKline, Research Triangle Park, NC, USA

^xNeurogesX, San Carlos, CA, USA

^yJohnson & Johnson, Raritan, NJ, USA

^zElan Pharmaceuticals, San Diego, CA, USA

^aaAbbott Laboratories, Lake Forest, IL, USA

^abUniversity of California San Diego, San Diego, CA, USA

^acUS Department of Veterans Affairs, Washington, DC, USA

^adEli Lilly & Co., Indianapolis, IN, USA

^*Corresponding author. Tel.: +1 585 275 3524; fax: +1 585 473 5007.

E-mail: [email protected]

Submitted March 10, 2004; revised September 1, 2004; accepted September 13, 2004.