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Scale-free amplitude modulation of low-frequency fluctuations in episodic migraine

Hodkinson, Duncan J.a,b,*; Lee, Daniellea,b; Becerra, Linoa,b; Borsook, Davida,b

doi: 10.1097/j.pain.0000000000001619
Research Paper
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Arrhythmic fluctuations in neural activity occur at many levels of the nervous system. Such activity does not have a characteristic temporal periodicity but can exhibit statistical similarities, most commonly power-law scaling behavior, which is indicative of scale-free dynamics. The recurrence of scaling laws across many different systems and its manifestation in behavior has prompted a search for unifying principles in human brain function. With this in mind, a focused search for abnormities in scale-free dynamics is of considerable clinical relevance to migraine and other clinical pain disorders. Here, we examined the scale-free properties of the resting-state functional magnetic resonance imaging (fMRI) signal in the broadband frequency range known to be related to spontaneous neural activity (0.01-0.1 Hz). In a large cohort of episodic migraine patients (N = 40), we observed that the strength of long-range temporal correlations in the fMRI signal (captured by the scaling exponent α) was significantly higher in the sensorimotor network compared with healthy controls. Increases in the scaling exponent were positively correlated with fMRI signal variance and negatively correlated with the patient's self-reported headache intensity. These changes in the fMRI signal suggest that the temporal structure of amplitude fluctuations carries valuable information about the dynamic state of the underlying neuronal networks and ensuing sensory impairments in migraine. The demonstrated scaling laws pose a novel quantitative approach for examining clinically relevant interindividual variability in migraine and other pain disorders.

Patients with migraine demonstrate increased strength of long-range temporal autocorrelations and scaling behavior in the sensorimotor network that may be of clinical relevance in migraine pathophysiology.

aDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States

bCenter for Pain and the Brain, Boston Children's, McLean and Massachusetts General Hospitals, Boston, MA, United States

*Corresponding author. Address: Department of Anesthesiology, Critical Care and Pain Medicine, Center for Pain and the Brain, Boston Children's Hospital, c/o 1 Autumn St, Boston, MA 02115, United States. Tel.: +447376916940. E-mail address: duncan.hodkinson@childrens.harvard.edu (D.J. Hodkinson).

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

© 2019 International Association for the Study of Pain
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