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Cortico-subcortical activation patterns for itch and pain imagery

Mochizuki, Hidekia,b,*; Baumgärtner, Ulfa; Kamping, Sandrac; Ruttorf, Michaelad; Schad, Lothar R.d; Flor, Hertac; Kakigi, Ryusukeb; Treede, Rolf-Detlefa

doi: 10.1016/j.pain.2013.06.007
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Summary This study found the key network important for emotion-driven covert motor response to itch (ie, scratch) and pain (eg, escape) using fMRI.

The imagery of itch and pain evokes emotional responses and covert motor responses (scratching to itch and withdrawal to pain). This suggests some similarity in cerebral mechanisms. However, itch is more socially contagious than pain, as evidenced by the fact that scratching behaviors can be easily initiated by watching itch-inducing situations, whereas withdrawal is less easily initiated by watching painful situations. Thus, we assumed that the cerebral mechanisms of itch imagery partly differ from those of pain imagery in particular with respect to motor regions. We addressed this issue in 18 healthy subjects using functional magnetic resonance imaging. The subjects were instructed to imagine itch and pain sensations in their own bodies while viewing pictures depicting stimuli associated with these sensations. Itch and pain imagery activated the anterior insular cortex (aIC) and motor-related regions such as supplementary motor area, basal ganglia, thalamus, and cerebellum. Activity in these regions was not significantly different between itch and pain imagery. However, functional connectivity between motor-related regions and the aIC showed marked differences between itch and pain imagery. Connectivity with the aIC was stronger in the primary motor and premotor cortices during pain imagery and stronger in the globus pallidus during itch imagery. These findings indicate that brain regions associated with imagery of itch are the same as those involved in imagery of pain, but their functional networks differ. These differences in brain networks may explain why motor responses to itch are more socially contagious than those related to pain.

aDepartment of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

bDepartment of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan

cDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

dComputer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

*Corresponding author at: Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan. Tel.: +81 564 55 7753; fax: +81 564 52 7913.

E-mail: motiz@nips.ac.jp

Submitted November 27, 2012; revised June 3, 2013; accepted June 4, 2013.

© 2013 Lippincott Williams & Wilkins, Inc.
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