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Estrogen status and psychophysical stress modify temporomandibular joint input to medullary dorsal horn neurons in a lamina-specific manner in female rats

Okamoto, Keiichiro*; Thompson, Randall; Katagiri, Ayano; Bereiter, David A.

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doi: 10.1016/j.pain.2013.03.009

Estradiol and behavioral stress modify temporomandibular joint-evoked trigeminal caudalis neural activity in a lamina-specific manner and enhance jaw muscle activity in female rats.

Estrogen status and psychological stress contribute to the expression of several chronic pain conditions including temporomandibular muscle and joint disorders (TMJD). Sensory neurons that supply the temporomandibular joint (TMJ) region terminate in laminae I and V of the spinal trigeminal nucleus (Vc/C1–2 region); however, little is known about lamina-specificity and environmental influences on the encoding properties of TMJ brainstem neurons. To test the hypothesis that Vc/C1–2 neurons integrate both interoceptive and exteroceptive signals relevant for TMJ nociception, we recorded TMJ-evoked activity in superficial and deep laminae of ovariectomized rats under high and low estradiol (E2) and stress conditions. Rats received daily injections of low (LE) or high (HE) dose E2 and were subjected to forced swim (FS) or sham swim conditioning for 3 days. The results revealed marked lamina-specificity in that HE rats displayed enhanced TMJ-evoked activity in superficial, but not deep, laminae independent of stress conditioning. By contrast, FS conditioned rats displayed increased background firing and TMJ-evoked activity of neurons in deep, but not superficial, laminae independent of E2 status. FS also enhanced TMJ-evoked masseter muscle activity and suggested the importance of deep dorsal horn neurons in mediating evoked jaw muscle activity. In conclusion, E2 status and psychophysical stress play a significant role in modifying the encoding properties of TMJ-responsive medullary dorsal horn neurons with a marked lamina-specificity.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, SE Minneapolis, MN 55455, USA

*Corresponding author. Address: Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, 18–186 Moos Tower, 515 Delaware St. SE Minneapolis, MN 55455, USA.


Submitted 21 November 2012; revised 20 February 2013; accepted 8 March 2013.

© 2013 Lippincott Williams & Wilkins, Inc.
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