ArticlesRisk factors for onset of chronic oro-facial pain – Results of the North Cheshire oro-facial pain prospective population studyAggarwal, Vishal R.a,*; Macfarlane, Gary J.b; Farragher, Tracey M.c; McBeth, JohncAuthor Information aOral Health Unit, School of Dentistry, Manchester Biomedical Research Centre, University of Manchester, Manchester M15 6FH, UK bAberdeen Pain Research Collaboration (Epidemiology Group), Institute of Applied Health Sciences, University of Aberdeen, School of Medicine and Dentistry, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK cArthritis Research Campaign Epidemiology Unit, Division of Epidemiology and Health Sciences, School of Medicine, University of Manchester, Manchester M13 9PT, UK *Corresponding author. Address: Oral Health Unit, School of Dentistry, University of Manchester, Oxford Road, Manchester M15 6FH. United Kingdom. Tel.: +44 0161 275 6623. E-mail address:firstname.lastname@example.org Submitted April 6, 2009; revised January 18, 2010; accepted February 24, 2010. Pain: May 2010 - Volume 149 - Issue 2 - p 354-359 doi: 10.1016/j.pain.2010.02.040 Buy Metrics Abstract Due to the cross-sectional nature of previous studies, whether mechanical factors predict the onset of Chronic oro-facial pain remains unclear. Aims of the current study were to test the hypotheses that self-reported mechanical factors would predict onset of Chronic oro-facial pain and that any observed relationship would be independent of the confounding effects of psychosocial factors and reporting of other unexplained symptoms. About 1735 subjects who had completed a baseline questionnaire were assessed at 2 year follow-up for the presence of Chronic oro-facial pain, psychosocial factors (anxiety and depression, illness behaviour, life stressors and reporting of somatic symptoms), mechanical dysfunction (facial trauma, grinding, phantom bite and missing teeth) and reporting of other unexplained symptoms (chronic widespread pain, irritable bowel syndrome and chronic fatigue). About 1329 subjects returned completed questionnaires (adjusted response rate 87%). About 56 (5%) reported new episodes of Chronic oro-facial pain at follow-up. Univariate analyses showed that age, gender, reporting of other unexplained symptoms, psychosocial factors and two self-report mechanical factors predicted the onset of Chronic oro-facial pain. However multivariate analysis showed that mechanical factors did not independently predict onset. The strongest predictors were health anxiety (Relative Risk (RR) 2.8, 95% CI 1.3–6.2), chronic widespread pain (RR 4.0 95% C.I. 2.2–7.4) and age (RR 0.2, 95% CI 0.1–0.7). The findings from this prospective study support the hypothesis that psychosocial factors are markers for onset of Chronic oro-facial pain. The efficacy of early psychological management of Chronic oro-facial pain to address these factors should be a priority for future investigations. © 2010 Lippincott Williams & Wilkins, Inc.