Clinical noteAcute, localised paroxysmal pain as the initial manifestation of focal seizures: A case report and a brief review of the literatureCharlesworth, Gavina,b; Soryal, Imadc; Smith, Shelaghb,d; Sisodiya, Sanjay M.b,e,*Author Information aNational Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK bNational Society for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK cConsultant in Rehabilitation Medicine and Neurology, The Queen Elizabeth Hospital, Birmingham B15 2TH, UK dConsultant in Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK eDepartment of Clinical & Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK *Corresponding author. Tel.: +44 20 3108 0125. E-mail address:firstname.lastname@example.org ARTICLE INFO Article history: Received January 25, 2008 Received in revised form November 5, 2008 Accepted November 10, 2008. Pain: February 2009 - Volume 141 - Issue 3 - p 300-305 doi: 10.1016/j.pain.2008.11.005 Buy Metrics Abstract ABSTRACT Pain is a rare manifestation of epileptic seizures. Yet, despite its rarity as a clinical entity, the pain associated with such seizures can be both severe and disabling. It thus remains important to consider epilepsy in the differential diagnosis of unexplained paroxysmal pain. By way of illustration, we present here a report of acute localised paroxysmal pain as the initial manifestation of focal epilepsy with EEG abnormalities in an otherwise neurodevelopmentally normal child. A brief discussion of the literature on epileptic pain then follows. © 2009 Lippincott Williams & Wilkins, Inc.