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pain1:A neuropathic pain QTL on mouse chromosome 15 in a C3H×C58 backcross

Devor, Marshalla; Gilad, Amitb; Arbilly, Michalb; Yakir, Benjaminc; Raber, Pninaa; Pisanté, Anneb; Darvasi, Arielb,*

doi: 10.1016/j.pain.2005.04.023
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We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.

aDepartment of Cell and Animal Biology, and Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel

bDepartment of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel

cDepartment of Statistics, Hebrew University of Jerusalem, Jerusalem 91904, Israel

*Corresponding author. Tel.: +972 2658 4303; fax: +972 2567 1179.

E-mail address:arield@cc.huji.ac.il

Received 25 November 2004; received in revised form 26 March 2005; accepted 25 April 2005.

© 2005 Lippincott Williams & Wilkins, Inc.
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