ArticleStrain-dependent modification of neuropathic pain behaviour in the rat hindpaw by a priming painful trigeminal nerve injuryBenoliel, Rafaela,∗; Eliav, Elia; Tal, MichaelbAuthor Information aDepartments of Oral Diagnosis, Oral Medicine and Oral Radiology, The Hebrew University, Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem, Israel bDepartment of Anatomy, The Hebrew University, Hadassah School of Dental Medicine. P.O. Box 12272, Jerusalem, Israel ∗Corresponding author. Tel.: +972-2-677-8567; fax: +972-2-643-9219 E-mail: [email protected] Received 11 July 2001; received in revised form 10 September 2001; accepted 17 September 2001. Pain: June 2002 - Volume 97 - Issue 3 - p 203-212 doi: 10.1016/S0304-3959(01)00428-6 Buy Metrics Abstract The aim of the present study was to test the behavioural effect of infraorbital (IO) chronic constriction injury (CCI) on the development of neuropathic pain in the rat hindpaw following sciatic nerve CCI performed 7 days later. Control groups consisted of rats that underwent sham infraorbital surgery followed by sciatic CCI at identical time points. Sensory testing of the rat's face and hindpaw was performed at baseline and at 4, 11, 14, 17 and 21 days postoperative (dpo) relative to the IOCCI, at which time all rats were euthanized. To test for strain differences the experiment was performed on Sprague–Dawley, Sabra and Lewis rats. In Lewis rats the trigeminal nerve injury significantly accelerated the development of hindpaw mechanoallodynia (11th, 14th and 17th dpo, unpaired t-test, P<0.05) and mechanohyperalgesia (14th and 17th dpo, unpaired t-test, P<0.05), following a second sciatic nerve CCI relative to the control group. This effect was not observed in Sprague–Dawley or Sabra rats. © 2002 Lippincott Williams & Wilkins, Inc.