Clinical noteTrigeminal autonomic cephalgia with periorbital ecchymosis, ocular hemorrhage, hypertension and behavioral alterationsAttanasio, Angeloa; D'Amico, Domenicoa; Frediani, Fabiob; Leone, Massimoa; Grazzi, Liciaa; Bianchi-Marzoli, Stefaniac; Usai, Susannaa; Bussone, Gennaroa,*Author Information aDepartment of Neurology, C. Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy bDepartment of Neurology, Policlinico S. Pietro, Ponte S. Pietro, Bergamo, Italy cDepartment of Ophthalmology, Scientific Institute S. Raffaele Hospital, Milan, Italy *Corresponding author. Tel.: +39-02-2394264; fax: +39-02-70638067 E-mail: [email protected] Submitted January 3, 2000; revised April 7, 2000; accepted April 11, 2000. Pain: October 2000 - Volume 88 - Issue 1 - p 109-112 doi: 10.1016/S0304-3959(00)00308-0 Buy Metrics Abstract We describe a 38-year-old male in whom severe unilateral headache was associated with marked palpebral edema, periorbital ecchymosis, lacrimation, conjunctival injection, nasal congestion and rhinorrhea. A second, less severe headache form developed subsequently. The patient often presented severe labile hypertension and behavioral disturbances during the crises, and there was an episode of intra-ocular hemorrhage. General, neurological and ophthalmological examinations revealed nothing remarkable. We discuss possible pathogenetic mechanisms and the nosology of this case within the trigeminal autonomic cephalgias. © 2000 Lippincott Williams & Wilkins, Inc.