Review ArticleCannabisfor migraine treatment: the once and future prescription? An historical and scientific reviewRusso, Ethan*Author Information Department of Neurology, Western Montana Clinic, 515 West Front Street, Missoula, MT 58907–7609, USA *Tel.: +1 406 3297238; fax: +1 406 3297453; e-mail: [email protected] Accepted January 26, 1998. Pain: May 1998 - Volume 76 - Issue 1 - p 3-8 doi: 10.1016/S0304-3959(98)00033-5 Buy Metrics Abstract Cannabis, or marijuana, has been used for centuries for both symptomatic and prophylactic treatment of migraine. It was highly esteemed as a headache remedy by the most prominent physicians of the age between 1874 and 1942, remaining part of the Western pharmacopoeia for this indication even into the mid-twentieth century. Current ethnobotanical and anecdotal references continue to refer to its efficacy for this malady, while biochemical studies of THC and anandamide have provided a scientific basis for such treatment. The author believes that controlled clinical trials of Cannabis in acute migraine treatment are warranted. © Lippincott-Raven Publishers.