Article: PDF OnlyThe effect of low-level laser therapy on musculoskeletal pain: A meta-analysisGam, Arne Nyholm∗,a; Thorsen, Hanneb; Lønnberg, FrankcAuthor Information aDepartment of Rheumatology, Bispebjerg Hospital, CopenhagenDenmark bInstitute of General Practice, University of Copenhagen, CopenhagenDenmark cDanish Institute of Clinical Epidemiology, CopenhagenDenmark ∗Correspondence to: Dr. Arne N. Gam, Lyngholmsvej 53, 2720 Vanløse, Denmark. Submitted May 1, 1992; revised August 6, 1992; accepted August 17, 1992. Pain: January 1993 - Volume 52 - Issue 1 - p 63-66 doi: 10.1016/0304-3959(93)90114-5 Buy Metrics Abstract A meta-analysis was undertaken of low-level laser therapy (LLLT) on musculoskeletal pain. A literature search revealed 23 LLLT trials and of these 17 were controlled trials. Ten were double blind and 7 were insufficiently blinded. Within the studies identified pain was assessed by visual analogue scale or by “some other indices of pain”. Nine double-blind trials and 4 controlled trials presented results in a form which allowed pooling of data. In the double-blind trials, the mean difference in pain between LLLT and placebo was 0.3% (S.E.(d) 4.6%, confidence limits −10.3–10.9%). In the insufficiently blinded trials the mean difference in pain was 9.5% (S.E.(d) 4.5%, confidence limits −2.9–21.8%). We conclude that LLLT has no effect on pain in musculoskeletal syndromes. © Lippincott-Raven Publishers.