Research report: PDF OnlyAxoplasmic transport block reduces ectopic impulse generation in injured peripheral nervesDevor, Marshall; Govrin-Lippmann, RuthAuthor Information Life Sciences Institute, Hebrew University of Jerusalem,Jerusalem 91904 Israel (Received 26 May 1982, accepted 7 September 1982) Pain: May 1983 - Volume 16 - Issue 1 - p 73-85 doi: 10.1016/0304-3959(83)90087-8 Buy Metrics Abstract Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic discharge and are sensitive to light pressure and to circulating adrenaline. Treatment of the nerve with colchicine or vinblastine at the time of the nerve section resulted in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway. © Lippincott-Raven Publishers.
