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An Exploratory Study on the Use of Event-Related Potentials as an Objective Measure of Auditory Processing and Therapy Effect in Patients With Tinnitus

A Transcranial Direct Current Stimulation Study

Jacquemin, Laure*,†; Mertens, Griet*,†; Van de Heyning, Paul*,†; Vanderveken, Olivier M.*,†; Topsakal, Vedat*,†; De Hertogh, Willem; Michiels, Sarah*,†,‡; Beyers, Jolien*,†; Moyaert, Julie*; Van Rompaey, Vincent*,†; Gilles, Annick*,†,§

doi: 10.1097/MAO.0000000000002380
AUDIOLOGY
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Objective: Treatment effect in tinnitus research is commonly evaluated by use of self-report questionnaires. As this is a solely subjective assessment method, the need for an objective measurement is paramount to genuinely evaluate the effects of therapeutic interventions. The current study explores the value of event-related potentials (ERPs) in the evaluation of high-definition transcranial direct current stimulation (HD-tDCS) for tinnitus treatment.

Study Design: Prospective exploratory study.

Setting: Tertiary referral center.

Patients: Twenty-two chronic tinnitus patients.

Intervention: HD-tDCS.

Main Outcome Measures: ERPs.

Results: The results show a significant shortening of the N1, P2, N2, and P3 latencies after HD-tDCS treatment. Moreover, the increased amplitude of the P2 and N2 peaks result in more salient and clear peaks, with the amplitude of N2 being significant larger after HD-tDCS. However, the ERP changes are not significantly correlated with the change in tinnitus functional index (TFI) total score.

Conclusions: The current study was the first to explore ERPs as objective measure in a study with HD-tDCS in tinnitus patients. Adding ERPs to the outcome measures in tinnitus research may lead to a better understanding of the therapeutic effect in the future. The results showed a shortening of ERP latencies and an increased N2 amplitude, possibly reflecting more effective sound processing with higher recruitment of synchronized neurons in the auditory cortex. Future studies should elaborate on these results, by collecting control data and adding a sham group, to provide a better insight in the underlying mechanism of the ERP changes after tinnitus treatment.

*University Department of Otorhinolaryngology and Head & Neck Surgery, Antwerp University Hospital, Edegem

Department of Translational Neurosciences

Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk

§Department of Human and Social Welfare, University College Ghent, Ghent, Belgium

Address correspondence and reprint requests to Laure Jacquemin, Dienst NKO, Wilrijkstraat 10, 2650 Edegem, Belgium; E-mail: laure.jacquemin@uza.be

The present research is financially supported by VLAIO (Agentschap Innoveren en Ondernemen) and a research grant from the FWO (Fonds voor Wetenschappelijk onderzoek Vlaanderen, Egmontstraat 5, 1000 Brussels) (T001916N).

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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