This study aimed to explore the feasibility of medical adhesive in the molding of oval window (OW) blockage in cadaver heads and to study the effect on bone conduction (BC).
Four cadaver heads were selected to establish OW blockage model. The daub type of medical adhesive was used to immobilize OW. The vibration properties of the round window membrane (VRWM) in response to the acoustic stimulation, and the vibration properties of the round window membrane and cochlear promontory (VCP) in response to the BC transducer B-71 stimulation were assessed by laser Doppler vibrometer in both pre-OW blockage and post-OW blockage.
After blocking the oval window, the mean values of the sound-induced velocities amplitude responses of the round window membrane by air conduction were decreased significantly beyond 30 dB in all measured frequencies (p < 0.05). The round window membrane relative velocity (VRWM/VCP) shows a decrease of about 1 dB at 1 and 3 kHz frequencies and a slight increase of around 0.5 dB from 4 to 8 kHz frequencies in post-OW blockage. However, it should also be noted that the VRWM/VCP is a significant decrease of 1.2 dB at 3 kHz in post-OW blockage compared with pre-OW blockage (p < 0.05).
Medical adhesive was available for the immobilization of oval window. In cadaver heads, the effect of OW blockage on the BC was the notching at 3 kHz.
*Department of Otorhinolaryngology Head and Neck Surgery
†ENT Institute, Eye and ENT Hospital of Fudan University
‡Hearing Medicine Key Laboratory, National Health and Family Planning Commission
§Facial Plastic and Reconstructive Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China
Address correspondence and reprint requests to Dr. Peidong Dai, Ph.D., ENT Institute, Eye and ENT Hospital of Fudan University, No. 83 Fenyang Road, Shanghai, China; E-mail: email@example.com
All applicable international, national, and/or institutional guidelines for the care and use of cadaver heads were followed.
K.C. and Y.C. contributed equally to the writing of this article.
This work was supported by the National Science and Technology Support Program (Grant No. 2015BAK31B01) and the Shanghai Committee of Science and Technology (Grant No. 13dz1940902), China.
The authors disclose no conflicts of interest.