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Clinical Validity of Quantified Visually Enhanced Vestibulo-ocular Reflex Test to Detect Horizontal Semicircular Canal Hypofunction

Rey-Martinez, Jorge*; Ninchritz, Elisabeth*; Palicio, Idoia*; Goiburu, Miren*; Casado, Carmen Maria; Altuna, Xabier*

doi: 10.1097/MAO.0000000000002090

Objective: To investigate the clinical validity of the mathematical measured VVOR test results to detect horizontal semicircular canal hypofunction.

Study Design: Prospective, nonrandomized, observational study.

Setting: Tertiary referral center, hospital.

Patients: Consecutive patients on first time visit to otoneurology unit.

Intervention(s): Diagnostic.

Main Outcome Measure(s): Values of statistical indicators of clinical validity for VVOR test to detect horizontal canal hypofunction were used considering vHIT horizontal aVOR gain values as gold standard.

Results: Area under curve of ROC curve for quantified VVOR testing was 0.92. Head movement frequency on VVOR test and contralateral VVOR gain were identified as significant influence factors of (unilateral) VVOR gain (p < 0.0001) on statistical linear model.

Conclusions: According to the obtained results, the quantified VVOR test has excellent clinical validity for detecting angular horizontal VOR hypofunction.

*Neurolotlogy Unit, ENT Department

Nursing, Hospital Universitario Donostia, Donostia, Spain

Address correspondence and reprint requests to Jorge Rey-Martinez, M.D., Ph.D., Departamento de Otorrinolaringología, Hospital Universitario Donostia, Paseo Doctor Beguiristain, 20014 Donostia, Spain; E-mail:

No funding was received for this research.

Ethical approval: Because of no new or exceptional interventions, only local ethical committee approval was required by the clinical researchers.

This clinical observational study was designed and performed in accordance with the ethical guidelines of the 1975 Declaration of Helsinki.

The authors disclose no conflicts of interest.

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