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Delayed Effect and Gain Restoration After Intratympanic Gentamicin for Menière's Disease

Martin-Sanz, Eduardo*,†; Diaz, Joaquin Yanes*,†; Esteban-Sanchez, Jonathan*,†; Sanz-Fernández, Ricardo*,†; Perez-Fernandez, Nicolas*,†

doi: 10.1097/MAO.0000000000001973

Objective: This study aimed to evaluate the changes in the VOR gain after intratympanic gentamicin therapy and to correlate them with the mid-term effects on the control of vertigo, in a population of Menière's disease patients.

Study Design: The study design was a prospective “Outcomes research.”

Setting: Tertiary referral center.

Patients: This study included 20 patients with unilateral Menière's disease refractory to medical therapy for at least 1 year, and treated with an on demand intratympanic gentamicin protocol.

Intervention: Therapeutic.

Main Outcome Measure: Audiometry, caloric testing, and a vHIT before beginning the protocol were performed. Patients underwent weekly vHIT assessments until a significant gain reduction was observed. Subsequently we performed vHIT tests 1 month after the therapy completion, and then every 3 months for at least 1 year.

Results: Complete vertigo control (class A) was achieved in 14 patients at the 12-month follow-up assessment. We observed a significant reduction in VOR gain values at the 3-week follow-up assessment. We found a significant correlation between the 1-month posttreatment ipsilateral hVOR gain and the rate of vertigo recurrence after the first IT gentamicin treatment (p = 0.012; r2 = 0.400). At the mid-term assessment, 10 patients exhibited a significant partial recovery of the hVOR gain.

Conclusions: The delayed effect of intratympanic gentamicin and the subsequent gain restoration are factors that may influence the patients’ outcome. The feasibility of the vHIT system makes it a useful tool to monitorize the VOR changes.

*Department of Otolaryngology, University Hospital of Getafe

Department of Otolaryngology, Clinica Universidad de Navarra, Madrid, Spain

Address correspondence and reprint requests to Eduardo Martin-Sanz, Ph.D., M.D., Department of Otolaryngologly, Hospital Universitario de Getafe, Autovía de Toledo, km 12,500, 28905 Getafe, Madrid, Spain; E-mail:

The authors disclose no conflicts of interest.

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