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Outcomes of Primary Radiosurgery Treatment of Glomus Jugulare Tumors

Systematic Review With Meta-analysis

Shapiro, Scott; Kellermeyer, Brian; Ramadan, Jad; Jones, Garret; Wiseman, Brian; Cassis, Adam

doi: 10.1097/MAO.0000000000001957
REVIEW ARTICLES
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Objective: 1) Determine tumor control, symptomatic control, and complication rates of primary radiosurgery (PRS) for treatment of glomus jugulare tumors (GJTs) via systematic review and meta-analysis. 2) Identify risk factors for these outcomes.

Data Sources: 1) Search of English articles in PubMed, Web of Science, Cochrane, and EBSCOhost databases from January 1950 to August 2017.

Study Selection: Inclusion criteria: 1) treated GJT patients who had no previous treatment with radiosurgery, 2) follow-up with magnetic resonance imaging for at least 12 months, 3) reported pre and posttreatment symptoms, tumor control, or complications for individual PRS patients or for PRS patients as a cohort.

Data Extraction: The following were extracted: number of patients, level of evidence, mean age, mean pretreatment tumor volume, tumor control rate, criteria for change in tumor size, symptom control rate, and complications. At the individual patient level the following were extracted: age, number of treatment fractions, total radiation dose to tumor margin, pretreatment tumor volume, Fisch or Glasscock–Jackson stage, pre- and posttreatment symptoms, tumor control, symptom control/improvement, length of follow-up, and complications.

Data Synthesis: Fifteen studies encompassing 91 patients met criteria. Tumor control was achieved in 92% of patients, symptom control in 93%, and complications occurred in 8%. There was one major complication. Smaller tumor volume predicted improvement in symptoms with PRS.

Conclusions: In the short term, PRS is safe and effective at controlling growth and clinical symptoms for patients with GJTs, though there exists significant selection bias, inconsistent reporting, and clinical heterogeneity among existing studies.

West Virginia University Department of Otolaryngology – Head and Neck Surgery, Morgantown, West Virginia

Address correspondence and reprint requests to Adam Cassis, M.D., West Virginia University Department of Otolaryngology – Head and Neck Surgery, Room 4520, Health Sciences Center South, Morgantown, WV 26506-9200; E-mail: acassis1@hsc.wvu.edu

The authors disclose no conflicts of interest.

Copyright © 2018 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company