Basic ScienceRound Window Membrane in Ménière's Disease: A Human Temporal Bone StudyYoda, Shigetoshi*†; Cureoglu, Sebahattin*; Shimizu, Shigetaka*‡; Morita, Norimasa†; Fukushima, Hisaki†; Sato, Teruyuki§; Harada, Tamotsu†; Paparella, Michael M.∥Author Information *Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.; †Department of Otolaryngology, Kawasaki Medical School, Kurashiki; ‡Department of Otolaryngology, Tokyo Medical University, Tokyo; §Department of Sensory Medicine, Division of Otorhinolaryngology & Head and Neck Surgery, Akita University School of Medicine, Akita, Japan; and ∥Paparella Ear Head and Neck Institute, Minneapolis, Minnesota, U.S.A. Address correspondence and reprint requests to Sebahattin Cureoglu, M.D., Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, Room 210, Lions Research Building, 2001 6th Street S.E., Minneapolis, MN 55455, U.S.A.; E-mail: [email protected] This work was supported by the National Institute on Deafness and Other Communication Disorders (grants R01 DC006452 and 3U24 DC008559-03S109), the International Hearing Foundation, and the Starkey Foundation. Otology & Neurotology: January 2011 - Volume 32 - Issue 1 - p 147-151 doi: 10.1097/MAO.0b013e318200a0e0 Buy Metrics Abstract Objectives: To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease. Methods: Twelve temporal bones from 6 patients with bilateral Ménière's disease, 44 temporal bones from 23 patients with unilateral Ménière's disease, and 102 age-matched normal temporal bones from 56 individuals were histopathologically examined. The thickness of the round window membrane was calculated from 3 different places. In addition, the presence of false round window membrane was investigated in temporal bones with Ménière's disease and compared to the normal temporal bones. Results: A significant difference in the mean thickness of the round window membrane was observed in temporal bones with Ménière's disease compared with normal temporal bones. There was no significant difference in the thickness of the round window membrane between the diseased side and contralateral side in patients with unilateral Ménière's disease. A false round membrane was observed in 9 (25.7%) of 35 Ménière's disease cases and in 5 (4.9%) of 102 normal temporal bones. Conclusion: The thickened nature of the round window membrane and the frequent presence of false round window membrane in patients with Ménière's disease may impede the intratympanic injection treatments. The thickened middle layer of the round window membrane may be related to perilymphatic pressure changes observed in patients with Ménière's disease. © 2011 Otology & Neurotology, Inc.