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Reliability of High-Resolution CT Scan in Diagnosis of Otosclerosis

Lagleyre, Sebastien*; Sorrentino, Tommaso*; Calmels, Marie-Noelle*; Shin, Young-Je*; Escudé, Bernard; Deguine, Olivier*; Fraysse, Bernard*

doi: 10.1097/MAO.0b013e3181c2a084

Objective: To assess the reliability of high-resolution computed tomographic scan (HRCT scan) for the diagnosis of otosclerosis and to determine its usefulness to predict hearing deterioration and surgical difficulties.

Study Design: Prospective study.

Setting: Tertiary reference center.

Patients: Two hundred nine ears (200 patients) presenting progressive conductive hearing loss with normal tympanic membrane, abnormal stapedial reflex, and scheduled for stapes surgery. The mean age was 47.3 years.

Intervention: All patients underwent HRCT scan before surgery (slice thickness of 0.6 to 1 mm). Stapedotomy was performed in 99% of cases.

Main Outcome Measures: High-resolution computed tomographic scan results were categorized as positive, doubtful, or negative. We classified a CT scan as positive for otosclerosis when a hypodense focus was seen around the otic capsule. Preoperative and postoperative air- and bone-conduction thresholds were collected.

Results: Of 209 HRCT scans, 84.2% were classified positive, 8.6% doubtful, and 7.2% negative. In all patients with positive CT scan, otosclerosis was confirmed in surgery. Among 15 negative cases, we found 4 minor malformations and 1 fracture of the stapes. Footplate incidents (mobilized, floating, or fractured footplate; 5.3%) occurred significantly more frequently when an HRCT scan was negative or doubtful (p = 0.05). Mean preoperative air-bone gap was 27.7 dB (standard deviation, 10). Mean postoperative air-bone gap was within 10 dB in 65% and within 20 dB in 92% of cases. Greater than 10 dB deterioration of bone-conduction thresholds occurred in 2% of cases. Mean preoperative and postoperative bone-conduction thresholds were significantly lower in cases of round window obliteration, pericochlear, or internal auditory canal hypodensities (p < 0.005 and p < 0.0001, respectively).

Conclusion: In our series, the sensitivity of HRCT scan to otosclerosis was 95.1%. Hypodense otosclerotic foci were mostly localized at the anterior part of footplate. Negative or doubtful cases were associated with the highest incidence of stapes footplate complications. Foci involving otic capsule, internal auditory canal, or round window led to a significantly higher risk of sensorineural hearing loss.

*Department of Otology-Neurotology and Skull Base Surgery, Purpan University Hospital; and †Department of Neuroradiology, Clinique Pasteur, Toulouse, France

Address correspondence and reprint requests to Sebastien Lagleyre, M.D., Service d'ORL et Otoneurologie, CHU Purpan, Place du Docteur Baylac, 31059 Toulouse Cedex, France; E-mail:

Additional Information: This work was presented in part at the 2nd International Symposium of the Politzer Society on Otolosclerosis and Stapes Surgery, May 8-10, 2008, Biarritz, France.

© 2009 Otology & Neurotology, Inc.