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Diagnostic Test Validation: Cochlear Hydrops Analysis Masking Procedure in Ménière's Disease

Ordóñez-Ordóñez, Leonardo Elías*†; Rojas-Roncancio, Eveling*; Hernández-Alarcón, Víctor*; Jaramillo-Safón, Rafael*; Prieto-Rivera, Jose*‡; Guzmán-Durán, Jose*‡; Lora-Falquez, Jose*‡; Escobar, Marcela§; Angulo-Martínez, Esther Sofía

doi: 10.1097/MAO.0b013e3181b11eb2
Vestibular Disorders
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Objective: To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease.

Study Design: Prospective validation study for a diagnostic test, study phase 2.

Setting: Tertiary referral centers.

Patients: Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated.

Interventions: Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.

Main Outcome Measure: Sensitivity, specificity, and other indicators of diagnostic validation.

Results: One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001).

Conclusion: If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.

*Universidad Militar Nueva Granada; †Otolaryngology Department, Hospital Universitario Clínica San Rafael; ‡Integrated Otolaryngology Department, Hospital Militar Central-Hospital Universitario Clínica San Rafael; §Unidad de Diagnóstico Audiológico; and ∥Infections and Tropical Health Magister, Bogotá, Colombia

Address correspondence and reprint requests to Leonardo Elías Ordóñez-Ordóñez, M.D., Otolaryngology Department, Hospital Militar Central, Transversal 3 # 49-00, tercer piso norte, Bogotá, Colombia; E-mail: otoleor@gmail.com, kokhlias@gmail.com

Presented as a scientific (clinical research) poster presentation in 2008 Annual Meeting and OTO EXPO, September 21-24, 2008, Chicago, IL. Reference number S235.

Abstract of preliminary report published in: Abstracts of the annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 21-24, 2008, Chicago, IL, USA [No authors listed]. Otolaryngol Head Neck Surg 2008;139(2 suppl 1):P10-200.

Financial disclosure: None.

© 2009 Otology & Neurotology, Inc.