To determine the diagnostic value of the cochlear hydrops analysis masking procedure (CHAMP) in patients with definite Ménière's disease.
Prospective validation study for a diagnostic test, study phase 2.
Tertiary referral centers.
Subjects with definite Ménière's disease (Group 1), differential diagnosis (Group 2: another audiovestibular diseases or neurologic disorders), and normal hearing (Group 3) were included. Sample sizes were calculated.
Study test (CHAMP) was compared with the current clinical criterion standard described by the guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.
Sensitivity, specificity, and other indicators of diagnostic validation.
One hundred ten cases completed the follow-up, and their results are presented. Sensitivity at 31.3% and specificity at 100% were found in subjects with definite Ménière's disease, features that are more helpful in confirming the diagnosis than in rejecting it. Group 1 showed significantly shorter latency delays than Groups 2 and 3 (p < 0.001).
If definite Ménière's disease is suspected, an abnormal result confirms the diagnosis; however, a normal result does not rule out the Ménière's disease diagnosis.
*Universidad Militar Nueva Granada; †Otolaryngology Department, Hospital Universitario Clínica San Rafael; ‡Integrated Otolaryngology Department, Hospital Militar Central-Hospital Universitario Clínica San Rafael; §Unidad de Diagnóstico Audiológico; and ∥Infections and Tropical Health Magister, Bogotá, Colombia
Address correspondence and reprint requests to Leonardo Elías Ordóñez-Ordóñez, M.D., Otolaryngology Department, Hospital Militar Central, Transversal 3 # 49-00, tercer piso norte, Bogotá, Colombia; E-mail: firstname.lastname@example.org, email@example.com
Presented as a scientific (clinical research) poster presentation in 2008 Annual Meeting and OTO EXPO, September 21-24, 2008, Chicago, IL. Reference number S235.
Abstract of preliminary report published in: Abstracts of the annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 21-24, 2008, Chicago, IL, USA [No authors listed]. Otolaryngol Head Neck Surg 2008;139(2 suppl 1):P10-200.
Financial disclosure: None.