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Feghali Joseph G. M.D. F.A.C.S.; Levin, Roger J. M.D.; Llena, Josefina M.D.; Bradley, Margaret K. Ph.D.; Kantrowitz, Allen B. M.D.
The American Journal of Otology: November 1995


Aggressive papillary tumors of the temporal bone are neoplasms that were recently re-classified as tumors of the endolymphatic sac. They typically invade the mastoid bone and otic capsule and can grow into the petrous apex. The authors have treated three patients with this rare neoplasm and grown one of the tumors in tissue culture. This report reviews the clinical presentation in the three patients and the immunohistochemical staining characteristics of the tumor and tumor culture as compared to those of the endolymphatic sac. Findings support the hypothesis that aggressive papillary lesions of the temporal bone arise from the endolymphatic sac. Additionally, it is noted that the tumor culture maintains the characteristics of the original tumor and thus provides an exciting laboratory model for further study of this rare neoplasm.

© 1995, The American Journal of Otology, Inc.