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Sacristán Jose A. M.D.; De Cos, Maria Angeles M.D.; Soto, Javier M.D.; Zurbano, Felipe M.D.; Pascual, Julio M.D; Tasis, Ana M.D.; Valle, Reina M.D.; Pablos, Carmen De M.D.
The American Journal of Otology: March 1993


Ototoxicity is probably the least acknowledged adverse reaction of erythromycin. The mechanism of erythromycin ototoxicity is still unknown. Here we report on two new cases of erythromycin-induced hearing loss. In both of them, serial evoked auditory brainstem potentials (EABPs) were obtained. The recorded EABPs showed absence of waves I to III during treatment with erythromycin, and normalization of all EABP waves after the administration of erythromycin had been stopped. Our findings support the hypothesis that erythromycin-induced hearing loss is attributable to a functional disorder in the peripheral parts of the auditory system.

© 1993, The American Journal of Otology, Inc.