PATHOPHYSIOLOGYPathogenesis of Tendon Rupture Secondary to Fluoroquinolone TherapyChilds, Sharon G. Author Information Sharon G. Childs, MS, APRN-BC, NP/CS, Adult/Acute Care Nurse Practitioner, Baltimore, MD. The author has no significant ties, financial or otherwise, to any company that might have an interest in the publication of this educational activity. Orthopaedic Nursing 26(3):p 175-182, May 2007. | DOI: 10.1097/01.NOR.0000276969.09808.2c Buy CE Test Metrics Abstract Tendon rupture related to trauma and corticosteroid injection, in and about tendon insertion sites, is well documented in the literature. Rupture of tendon after fluoroquinolone therapy has been identified in the recent past. Both short- and long-term courses of antibiotic treatment with fluoroquinolone may precipitate alteration in tendon matrix leading to tendinopathy with subsequent rupture. The pathogenesis of tendon rupture secondary to fluoroquinolone therapy is presented. © 2007 National Association of Orthopaedic Nurses
