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Hydrogel Contact Lens Binding Induced by Contact Lens Rewetting Drops

NICHOLS, JASON J. OD, MPH, PhD, FAAO; SINNOTT, LORAINE T. PhD; KING-SMITH, P EWEN PhD, FAAO; NAGAI, HIDENOBU BS; TANIKAWA, SADAYASU MS

Optometry and Vision Science: April 2008 - Volume 85 - Issue 4 - p 236-240
doi: 10.1097/OPX.0b013e3181694fa9
Original Article
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Purpose. To investigate alterations in prelens tear film (PLTF), contact lens (CL), and postlens tear film (PoLTF) thicknesses and contact lens movement associated with boric acid-containing rewetting drops.

Methods. This was a single-center, randomized, double-masked clinical trial. Following etafilcon A lens application, baseline lens movement and interferometric measures (PLTF, CL, PoLTF thicknesses) were captured. A randomly assigned drop (either a low or high boric acid-containing drops) was applied to both eyes, followed immediately by lens movement and interferometric measures. After a 2-h washout period (spectacle wear), subjects returned for testing with the alternative drop. Statistical analyses addressed pre- to postdrop changes in lens movement and PLTF, CL, and PoLTF thickness.

Results. The presence of a drop alone lead to substantial decreases in contact lens movement (general reduction of 0.45 mm), but the reduction was not related to drop type. The presence of a drop led to an increase in PLTF thickness (∼0.14 μm), again regardless of the drop type. Both the general presence of a rewetting drop and drop type lead to an increase in CL center thickness (lower boric acid drop = 0.31 μm and higher boric acid drop = 1.13 μm). Both the general presence of a rewetting drop and the drop type lead to a significant decrease in PoLTF thickness, whereby the lower boric acid drop lead to a decrease of 0.28 μm and the higher boric acid drop lead to a decrease of 0.73 μm.

Conclusions. Boric acid-containing rewetting drops were shown to be associated with a significant reduction in lens movement with a concurrent increase in lens center thickness and reduction in PoLTF thickness. The higher boric acid-containing drop was associated with more substantial increases in lens center thickness and decreases in PoLTF thickness.

The Ohio State University, College of Optometry, Columbus, Ohio (JJN, LTS, PEK-S), and Menicon Co., LTD, Research & Development Division, Kasugai, Aichi, Japan (HN, ST)

Received October 2, 2007; accepted December 17, 2007.

© 2008 American Academy of Optometry