1Columbia Vagelos College of Physicians and Surgeons, New York, New York
2Department of Psychology, Columbia University, New York, New York
3New York Eye and Ear Infirmary, New York, New York
4Department of Ophthalmology, Montefiore Medical Center, New York, New York
5Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York
Supplemental Digital Content: Appendix Figure A1 available at https://links.lww.com/OPX/A489. An example of segmentation and alignment errors. (A) The b-scan for time 1. (B) The b-scan for time 2. (C) The cRNFL thickness profile for time 1. (D) The cRNFL thickness profile for time 2. The red solid vertical lines indicate the position of the major temporal vessels based on time 1, while the dashed red line shows the position of the ‘shifted’ blood vessel on time 2. The black and white arrows show regions where there are segmentation errors (eye ID 1).
Appendix Figure A2 available at https://links.lww.com/OPX/A490. An example of an ‘apparent change in total retinal thickness’ (aΔRT) artifact. (A) The b-scan for time 1. (B) The b-scan for time 2. (C) The cRNFL thickness profiles for the first (gray) and second (black) times. The insets (left panels) show the aΔRT error – the vertical white lines have the same length and indicate the distance from the inner plexiform layer/outer plexiform layer boundary to an identifiable marker in the choroid. In this example, the b-scan in time 1 is slightly magnified compared to the b-scan in time 2 (eye ID 6).
Appendix Figure A3 available at https://links.lww.com/OPX/A491. An example of progression. (A) The circumpapillary b-scan from time 1. (B) The b-scan for time 2. (C) The cRNFL thickness profiles for the first (gray) and second (black) times. The black and white arrows show regions of progression (eye ID 4).
Appendix Figure A4 available at https://links.lww.com/OPX/A492. Examples of clear change in the GCLP thickness map but ΔGGCLP values of only –3.1 and –6.3 respectively, showing that local changes in GCLP can be missed. (A) Eye ID 12. (B) Eye ID 8.
Submitted: September 23, 2020
Accepted: January 30, 2021
Funding/Support: National Eye Institute (EY-02115; to DCH) and National Eye Institute (EY-025253; to CGDM).
Conflict of Interest Disclosure: Heidelberg Engineering provided financial and material (equipment) support but had no role in the study design, conduct, analysis and interpretation, or writing of the report.
The authors listed report a financial conflict of interest: DCH: Topcon, Inc. (research support, consultant) and Heidelberg Engineering (research support, consultant). CGDM: Carl Zeiss Meditec, Inc. (instrument support, consultant), Topcon, Inc. (instrument support), Heidelberg Engineering (instrument support), Novartis, Inc. (consultant), Galimedix, Inc. (consultant), Lin Biosciences, Inc. (consultant), Reichert, Inc. (consultant), and Perfuse Therapeutics (consultant). ET: Topcon, Inc. (lecture fees).
Author Contributions: Conceptualization: ET, CGDM, DCH; Data Curation: AT, DJ; Formal Analysis: AT, ET, ZZZ, SLB, DCH; Investigation: AT, ET; Methodology: AT, ET, ME, DCH; Project Administration: DCH; Resources: CGDM, DCH; Supervision: CGDM, DCH; Validation: ET, SLB, ME, DCH; Visualization: ET; Writing – Original Draft: AT, ET, DCH; Writing – Review & Editing: ZZZ, SLB, ME, DJ, CGDM.
Supplemental Digital Content: Direct URL links are provided within the text.