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Visual Acuity Is Not the Best at the Preferred Retinal Locus in People with Macular Disease

Bernard, Jean-Baptiste, PhD1,2; Chung, Susana T. L., OD, PhD, FAAO1*

doi: 10.1097/OPX.0000000000001229
Original Investigations

SIGNIFICANCE Little is known about how the preferred retinal locus (PRL) develops in patients with macular disease. We found that acuity is worse at the PRL than at other retinal locations around the scotoma, suggesting that the selection of the PRL location is unlikely to be based on optimizing acuity.

PURPOSE Following the onset of bilateral macular disease, most patients adopt a retinal location outside the central scotoma, the PRL, as their new retinal location for visual tasks. Very little information is known about how the location of a PRL is chosen. In this study, we tested the hypothesis that the selection of the location for a PRL is based on optimizing visual acuity, which predicts that acuity is the best at the PRL, compared with other retinal locations.

METHODS Using a scanning laser ophthalmoscope that allowed us to position visual targets at precise retinal locations, we measured acuity psychophysically using a four-orientation Tumbling-E presented at the PRL and at multiple (ranged between 23 and 36 across observers) locations around the scotoma for five observers with bilateral macular disease.

RESULTS For all five observers, the acuity at the PRL was never the best among all testing locations. Instead, acuities were better at 15 to 86% of the testing locations other than the PRL, with the best acuity being 17 to 58% better than that at the PRL. The locations with better acuities did not cluster around the PRL and did not necessarily lie at the same distance from the fovea or the PRL.

CONCLUSIONS Our finding that acuity is worse at the PRL than at other locations around the scotoma implies that the selection of the PRL location is unlikely to be based on optimizing acuity.

1School of Optometry, University of California, Berkeley, Berkeley, California

2Aix-Marseille Université, Laboratoire de Psychologie Cognitive, CNRS, Marseille, France *s.chung@berkeley.edu

Supplemental Digital Content: Appendix Figure A1, available at http://links.lww.com/OPX/A343. Acuity thresholds are plotted (green circles) for each observer as a function of the distance of the testing locations from the edge of the scotoma, with the green solid line representing the best-fit regression line to the data-set. The correlation coefficient of the regression line is given in the bottom right corner in each panel. None of the correlation coefficients are significant. The black cross in each panel plots the acuity threshold at the preferred retinal locus. Error bars represent ± 1 standard error of the mean.

Submitted: September 4, 2017

Accepted: February 18, 2018

Funding/Support: National Eye Institute (R01-EY012810; to STLC).

Conflict of Interest Disclosure: None of the authors have reported a financial conflict of interest.

Author Contributions: Conceptualization: STLC; Data Curation: J-BB, STLC; Formal Analysis: J-BB, STLC; Funding Acquisition: STLC; Investigation: J-BB, STLC; Methodology: J-BB, STLC; Project Administration: STLC; Resources: STLC; Software: J-BB; Supervision: STLC; Validation: J-BB, STLC; Visualization: J-BB, STLC; Writing – Original Draft: J-BB, STLC; Writing – Review & Editing: J-BB, STLC.

Supplemental Digital Content: Direct URL links are provided within the text.

© 2018 American Academy of Optometry