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Case Report: Use of Self-retained Cryopreserved Amniotic Membrane in the Treatment of Acute Chemical Ocular Burn

Shupe, Adam T. OD1,2; Cheng, Anny M. S. MD3,4*

doi: 10.1097/OPX.0000000000001132

SIGNIFICANCE Ocular chemical injury is a medical emergency in which immediate treatment is critical to prevent visual morbidity. We report a severe ocular burn case that illustrates in-office management to promote rapid re-epithelialization and reduce inflammation to restore ocular surface integrity.

PURPOSE To report a case of severe acid burn that was managed successfully with self-retained cryopreserved amniotic membrane (AM).

METHODS A 43-year-old man presented with complaints of pain, light sensitivity, and blurred vision in both eyes 1 day after ocular exposure to acid. Symptoms and signs were more severe in the left eye. Examination revealed diffuse conjunctival inflammation and extensive corneal, conjunctival, and limbal epithelial defects in the left eye; hence, application of cryopreserved AM was performed.

RESULTS Placement of three self-retained AMs over a 10-day period resulted in resolution of symptoms, reduction in inflammation, complete re-epithelialization of corneal and limbal defects, and improvement of visual acuity from 20/50 to 20/20. Intriguingly, areas of conjunctival inflammation not covered by the AM remained inflamed.

CONCLUSIONS In this case of acute chemical burn, application of self-retained AM 24 hours after injury was effective in promoting ocular surface healing, reducing inflammation, and restoring visual acuity.

1Royo Eye Care, Marysville, California

2Medical Center Eye Clinic, Salem, Oregon

3Florida International University, Herbert Wertheim College of Medicine, Miami, Florida

4Ocular Surface Center, Miami, Florida *

Submitted: October 28, 2016

Accepted: June 14, 2017

Funding/Support: None of the authors have reported funding/support.

Conflict of Interest Disclosure: ATS is a consultant of BioTissue, Inc.

Author Contributions and Acknowledgments: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft, Writing – Review & Editing: ATS, AMSC.

The authors thank Sean Tighe for assisting in editing the text and Dr. Scheffer C. G. Tseng for his great support.

© 2017 American Academy of Optometry