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Latanoprost-Induced Prostaglandin-Associated Periorbitopathy

Tan, Joseph*; Berke, Stanley*

doi: 10.1097/OPX.0b013e31829d8dd7

Purpose To report, with supporting photo-documentation, cases of latanoprost-induced prostaglandin-associated periorbitopathy (PAP).

Case Series Retrospective small case series with three cases. Chart review with photo-documentation of clinical features of prostaglandin-associated periorbitopathy resulting from latanoprost use. Patients developed involution of dermatochalasia, blepharoptosis, deepening of orbital sulci, and flattening of lower eyelid bags after a mean usage period of 6 years (3 to 8 years).

Conclusions Latanoprost can cause PAP, although it has a lower risk and longer latency of onset than those with bimatoprost and travoprost. Clinicians should be aware of this side effect and monitor for signs periodically. Chronic unilateral prostaglandin use may cause unfavorable asymmetry in the appearance of the periorbital area.


Nassau University Medical Center, East Meadow (JT, SB), and Berke Eye Care, Westbury, New York (SB).

Joseph Tan Nassau University Medical Center 2201 Hempstead Turnpike East Meadow, New York 11554 e-mail:

© 2013 American Academy of Optometry