To evaluate white sphere kinetic perimetry
(WSKP) as a test of the peripheral visual field
in young children
with a history of epilepsy and treatment with Vigabatrin
(VGB). VGB is an antiepileptic medication that is associated with visual field
Thirty-one VGB patients and 10 control subjects, median age 6 years, were recruited. Visual field
extent on the major oblique meridia was tested with a 6° white sphere and WSKP, a method used by Quinn et al. to study field extent in children
with retinopathy of prematurity. The same meridia were tested using Goldmann kinetic perimetry
(GKP; 1.7° target) in those who were capable. Monocular and binocular tests were conducted. Visual field
extent for WSKP and GKP were compared in VGB patients and control subjects.
Twenty-eight of 31 VGB patients were testable with binocular WSKP and their median visual field
extents were smaller than controls. In 8 of 28 (29%) VGB patients, binocular field extents were smaller than the minimum in the control subjects. Monocular WSKP results did not differ between VGB patients and control subjects. Nine VGB patients were testable with both WSKP and GKP; visual field
extents did not differ between tests.
WSKP is feasible in VGB patients, even in those with developmental delays. WSKP has the potential to detect visual field
constriction associated with VGB use.