Chin, Brandon B.S.* ; Sassoon, Jodi M.D.†; Farhat, Nada M.D.†; Shinder, Roman M.D. F.A.C.S.*
Author Information
* Department of Ophthalmology, Brooklyn, SUNY Downstate Medical Center, New York, U.S.A.
†Department of Pathology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, U.S.A.
Accepted for publication April 18, 2019.
The authors disclose no financial or conflicts of interest.
Address correspondence and reprint requests to Roman Shinder, M.D., Department of Ophthalmology, SUNY Downstate Medical Center, 451 Clarkson Ave, E bldg, 8th Fl, Suite C, Brooklyn, NY 11203. E-mail: [email protected]
doi: 10.1097/IOP.0000000000001407
A 53-year-old female presented with a several-month history of a painless left eyelid lesion. Exam revealed a circumscribed pink 0.5 × 0.4 cm superficial papule in the central left upper eyelid superior to the tarsus (Fig. A ). Excisional biopsy disclosed a lymphocyte proliferation (Fig. B ) that was polytypic with a minority staining for the B-cell marker CD20 (Fig. C ) and the majority staining for the T-cell marker CD3 (Fig. D ). Gene rearrangement also confirmed polyclonality and the diagnosis of eyelid reactive lymphoid hyperplasia (LH). Systemic workup was negative and surveillance has shown the patient to be free of both local and distant disease during 14 months of follow-up. Although ocular adnexal LH is not uncommon, LH of the eyelid is exceptionally rare.
A , Clinical photograph showing left upper lid papule. B , Histopathology of biopsy specimen displaying a polytypic proliferation of lymphocytes (H&E, 20X). The minority of cells stained with CD20 (C, 40X), while the majority stained with CD3 (D, 40X).
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