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Rapidly Progressive Conjunctival Squamous Cell Carcinoma With Orbital Invasion

Raevis, Joseph M.D.*; Lin, Bo M.D.; Shinder, Roman M.D. F.A.C.S.*

Ophthalmic Plastic & Reconstructive Surgery: July/August 2019 - Volume 35 - Issue 4 - p e105
doi: 10.1097/IOP.0000000000001318
OPRS Images

*Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York

Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York, U.S.A.

Accepted for publication December 13, 2018.

The authors have no financial or conflicts of interest to disclose.

Address correspondence and reprint requests to Roman Shinder, M.D., Department of Ophthalmology, SUNY Downstate Medical Center, 451 Clarkson Ave, E bldg, 8th Fl, Suite C, Brooklyn, NY 11203. E-mail:

A 41-year-old HIV-negative man with a history of alcoholism and tobacco use presented with a painless right lower eyelid mass for 3 months (Fig. A). On examination, the lesion appeared to originate from the conjunctiva with intact eyelid epidermis (Fig. B). There was no lymphadenopathy. Biopsy revealed moderately differentiated squamous cell carcinoma with keratin pearls (Fig. C). The patient was lost to follow-up and returned 2 months later with a rapidly enlarged lesion of the eyelid and anterior orbit (Fig. D), with radiographic evidence of orbital invasion (Fig. E). After a negative systemic work-up, the patient underwent an orbital exenteration and subsequent radiotherapy. The patient remains free of disease 8 months following surgery.

© 2019 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.