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Adenosquamous Carcinoma Arising in Bulbar Conjunctiva

Kase, Satoru M.D., Ph.D.; Ishida, Susumu M.D., Ph.D.

Ophthalmic Plastic & Reconstructive Surgery: September/October 2019 - Volume 35 - Issue 5 - p e109–e110
doi: 10.1097/IOP.0000000000001433
Case Reports
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Adenosquamous carcinoma is a highly aggressive tumor, which can rarely arise from the ocular surface. The authors herein report a patient who presented with a 5 mm mass on the temporal conjunctiva that was clinically diagnosed as squamous cell carcinoma. The lesion was surgically resected with cryopexy to the conjunctival wound edges. Histopathology and immunoractivity confirmed the diagnosis of adenosquamous carcinoma. Following topical interferon alpha 2b for 3 months, there has been no recurrence or distant metastsis during a follow-up of 12 months.

Adenosquamous carcinoma is a highly malignant tumor that causes subsequent patients’ death; however, little is known about conjunctival adenosquamous carcinoma. This study herein describes a new case with adenosquamous carcinoma in the bulbar conjunctiva and characteristic histologic findings.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Accepted for publication May 8, 2019.

The authors have no financial or conflicts of interest to disclose.

Address correspondence and reprint requests to Satoru Kase, M.D., Ph.D., Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. E-mail: kaseron@med.hokudai.ac.jp

© 2019 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.